ArticleThe journal of nutrition, health & aging2014
Low muscle mass in older men: the role of lifestyle, diet and cardiovascular risk factors.
Article in The journal of nutrition, health & aging, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- Effects of exercise interventions on inflammatory biomarker levels in older adults with frailty and/or sarcopenia: a systematic review and meta-analysis.Frontiers in immunology · 2026Pooled it
- Relationship between sarcopenia and physical activity in older people: a systematic review and meta-analysis.Clinical interventions in aging · 2017Pooled it
- Effects of a moderate-to-high intensity resistance circuit training on fat mass, functional capacity, muscular strength, and quality of life in elderly: A randomized controlled trial.Scientific reports · 2019Trial
- C-Reactive Protein and Resistance Exercise in Community Dwelling Old Adults.The journal of nutrition, health & aging · 2015Trial
- Effect of protein source during weight loss on body composition, cardiometabolic risk and physical performance in abdominally obese, older adults: a pilot feeding study.The journal of nutrition, health & aging · 2015Trial
- Human β-Cell Dedifferentiation and Diabetes.Journal of diabetes · 2026Review
- Chronic inflammation as a driving factor for sarcopenia: an update on pathophysiology and future therapeutic targets.Frontiers in pharmacology · 2026Review
- Sarcopenia and Cachexia in Older Patients with Cancer: Pathophysiology, Diagnosis, Impact on Outcomes, and Management Strategies.Drugs & aging · 2025Review
- Study on body composition characteristics and influencing factors of sarcopenia status among older adults in Shanghai: a cross-sectional study.Journal of health, population, and nutrition · 2025Article
- Muscle Strength and Biochemical Markers as Predictors of Depression in Hemodialysis Patients: A Cross-Sectional Study.Clinical nutrition research · 2023Article
- Modifiable contributing factors to COVID-19: A comprehensive review.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2023Review
- Relationship between hyperhomocysteinemia and coexisting obesity with low skeletal muscle mass in asymptomatic adult population.Scientific reports · 2022Article
- Association between Elevated Plasma Homocysteine and Low Skeletal Muscle Mass in Asymptomatic Adults.Endocrinology and metabolism (Seoul, Korea) · 2022Article
- Causal effects of homocysteine levels on the components of sarcopenia: A two-sample mendelian randomization study.Frontiers in genetics · 2022Article
- Associations between Circulating Inflammatory Biomarkers and Indicators of Muscle Health in Older Men and Women.Journal of clinical medicine · 2021Article
- Proteomic profiling of low muscle and high fat mass: a machine learning approach in the KORA S4/FF4 study.Journal of cachexia, sarcopenia and muscle · 2021Article
- Evaluation of organ glucose metabolism byScientific reports · 2021Article
- The Critical Role of Oxidative Stress in Sarcopenic Obesity.Oxidative medicine and cellular longevity · 2021Review
- Innovations in Geroscience to enhance mobility in older adults.Experimental gerontology · 2020Review
- Dietary Intake, D3Cr Muscle Mass, and Appendicular Lean Mass in a Cohort of Older Men.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo explore associations between low muscle mass and a wide range of lifestyle, dietary and cardiovascular risk factors in older men including metabolic risk factors, markers of inflammation, endothelial dysfunction and coagulation.
designCross-sectional study.
settingBritish Regional Heart Study.
participants4252 men aged 60-79 years. MEASUREMENTS: PARTICIPANTS attended a physical examination in 1998-2000, and completed a general questionnaire and a food frequency questionnaire. Low muscle mass was assessed by two measures: midarm muscle circumference (MAMC) and fat-free mass index (FFMI). Associations between risk factors and low muscle mass were analysed using logistic regression.
resultsPhysical inactivity, insulin resistance, C-reactive protein, von Willebrand factor and fibrinogen were associated with significantly increased odds of low MAMC and FFMI after adjustment for body mass index, lifestyle characteristics and morbidity. Those with higher percent energy intake from carbohydrates showed decreased odds of low MAMC (OR: 0.73, 95% CI: 0.55-0.96) and FFMI (OR: 0.76, 95% CI: 0.58-0.99). Other dietary variables, smoking, alcohol intake, D-dimer, interleukin 6 and homocysteine showed no important associations with MAMC and FFMI.
conclusionIncreasing physical activity, consuming a diet with a high proportion of energy from carbohydrates, and taking steps to prevent insulin resistance and reduce inflammation and endothelial dysfunction may help to reduce the risk of low muscle mass in older men.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.