ArticleGenetics2014
The nature and extent of mutational pleiotropy in gene expression of male Drosophila serrata.
Article in Genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 58 citations in OpenAlex.
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- Stabilizing and directional selection shape the genetic variation of gene expression in the transcriptome of Chlamydomonas.Molecular biology and evolution · 2026Article
- Tissue-specific differences of gene expression variance in mutation accumulation lines of mice.Heredity · 2026Article
- Promoters Constrain Evolution of Expression Levels of Essential Genes in Escherichia coli.Molecular biology and evolution · 2024Article
- Rapid evolutionary change in trait correlations of single proteins.Nature communications · 2024Article
- The Effects of De Novo Mutation on Gene Expression and the Consequences for Fitness in Chlamydomonas reinhardtii.Molecular biology and evolution · 2024Article
- The evolution of genetic covariance and modularity as a result of multigenerational environmental fluctuation.Evolution letters · 2023Article
- Genetic independence between traits separated by metamorphosis is widespread but varies with biological function.Proceedings. Biological sciences · 2023Article
- Detecting natural selection in trait-trait coevolution.BMC ecology and evolution · 2023Article
- Contributions of mutation and selection to regulatory variation: lessons from thePhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Article
- Systems genetics in the rat HXB/BXH family identifies Tti2 as a pleiotropic quantitative trait gene for adult hippocampal neurogenesis and serum glucose.PLoS genetics · 2022Article
- Integrating genomics and multivariate evolutionary quantitative genetics: a case study of constraints on sexual selection inProceedings. Biological sciences · 2021Article
- The contribution of mutation and selection to multivariate quantitative genetic variance in an outbred population ofProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Correlational selection in the age of genomics.Nature ecology & evolution · 2021Review
- Molecular and evolutionary processes generating variation in gene expression.Nature reviews. Genetics · 2021Review
- The GeneG3 (Bethesda, Md.) · 2020Article
- Empirical measures of mutational effects define neutral models of regulatory evolution inProceedings of the National Academy of Sciences of the United States of America · 2019Article
- EIGENVALUE DISTRIBUTIONS OF VARIANCE COMPONENTS ESTIMATORS IN HIGH-DIMENSIONAL RANDOM EFFECTS MODELS.Annals of statistics · 2019Article
- Genetic and environmental variation in transcriptional expression of seminal fluid proteins.Heredity · 2019Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The nature and extent of mutational pleiotropy remain largely unknown, despite the central role that pleiotropy plays in many areas of biology, including human disease, agricultural production, and evolution. Here, we investigate the variation in 11,604 gene expression traits among 41 mutation accumulation (MA) lines of Drosophila serrata. We first confirmed that these expression phenotypes were heritable, detecting genetic variation in 96% of them in an outbred, natural population of D. serrata. Among the MA lines, 3385 (29%) of expression traits were variable, with a mean mutational heritability of 0.0005. In most traits, variation was generated by mutations of relatively small phenotypic effect; putative mutations with effects of greater than one phenotypic standard deviation were observed for only 8% of traits. With most (71%) traits unaffected by any mutation, our data provide no support for universal pleiotropy. We further characterized mutational pleiotropy in the 3385 variable traits, using sets of 5, randomly assigned, traits. Covariance among traits chosen at random with respect to their biological function is expected only if pleiotropy is extensive. Taking an analytical approach in which the variance unique to each trait in the random 5-trait sets was partitioned from variance shared among traits, we detected significant (at 5% false discovery rate) mutational covariance in 21% of sets. This frequency of statistically supported covariance implied that at least some mutations must pleiotropically affect a substantial number of traits (>70; 0.6% of all measured traits).
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