ArticleMarine drugs2014
Induced marine fungus Chondrostereum sp. as a means of producing new sesquiterpenoids chondrosterins I and J by using glycerol as the carbon source.
Article in Marine drugs, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Advances on anticancer fungal metabolites: sources, chemical and biological activities in the last decade (2012-2023).Natural products and bioprospecting · 2024Article
- Cytotoxic Compounds from Marine Fungi: Sources, Structures, and Bioactivity.Marine drugs · 2024Review
- Hirsutanol A inhibits T-acute lymphocytic leukemia Jurkat cell viability through cell cycle arrest and p53-dependent induction of apoptosis.Experimental and therapeutic medicine · 2021Article
- Species Diversity and Secondary Metabolites ofMolecules (Basel, Switzerland) · 2021Review
- Monarubins A-C from the Marine Shellfish-Associated FungusMarine drugs · 2020Article
- Bioactive Secondary Metabolites from Octocoral-Associated Microbes-New Chances for Blue Growth.Marine drugs · 2018Review
- Linear Triquinane Sesquiterpenoids: Their Isolation, Structures, Biological Activities, and Chemical Synthesis.Molecules (Basel, Switzerland) · 2018Review
- Marine Fungi: A Source of Potential Anticancer Compounds.Frontiers in microbiology · 2017Review
- Additional New Cytotoxic Triquinane-Type Sesquiterpenoids Chondrosterins K-M from the Marine Fungus Chondrostereum sp.Marine drugs · 2016Article
- Potential Pharmacological Resources: Natural Bioactive Compounds from Marine-Derived Fungi.Marine drugs · 2016Review
- Five New Cytotoxic Metabolites from the Marine Fungus Neosartorya pseudofischeri.Marine drugs · 2016Article
- Bioactive terpenes from marine-derived fungi.Marine drugs · 2015Review
- Exploring the chemodiversity and biological activities of the secondary metabolites from the marine fungus Neosartorya pseudofischeri.Marine drugs · 2014Article
- Pseudaboydins A and B: novel isobenzofuranone derivatives from marine fungus Pseudallescheria boydii associated with starfish Acanthaster planci.Marine drugs · 2014Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chondrostereum sp., a marine fungus isolated from a soft coral Sarcophyton tortuosum, can yield hirsutane framework sesquiterpenoids. However, the metabolites profiles vary dramatically with the composition change of the culture media. This fungus was cultured in a liquid medium containing glycerol as the carbon source, and two new metabolites, chondrosterins I and J (1 and 2), were obtained. Their structures were elucidated primarily based on MS, NMR and X-ray single-crystal diffraction data. By comparison with the known hirsutane sesquiterpenoids, chondrosterins I and J have unique structural features, including a methyl was migrated from C-2 to C-6, and the methyl at C-3 was carboxylated. Compound 2 exhibited potent cytotoxic activities against the cancer cell lines CNE-1 and CNE-2 with the IC50 values of 1.32 and 0.56 μM.
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