ArticleRheumatology international2014
Association between helplessness, disability, and disease activity with health-related quality of life among rheumatoid arthritis patients in a multiethnic Asian population.
Article in Rheumatology international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Measurement properties of Chinese-version assessment tools of self-efficacy in patients with rheumatoid arthritis: a COSMIN-based systematic review.Journal of patient-reported outcomes · 2026Pooled it
- Pain beliefs and problems in functioning among people with arthritis: a meta-analytic review.Journal of behavioral medicine · 2016Pooled it
- Tofacitinib with conventional synthetic disease-modifying antirheumatic drugs in Chinese patients with rheumatoid arthritis: Patient-reported outcomes from a Phase 3 randomized controlled trial.International journal of rheumatic diseases · 2018Trial
- The association of intensity of joint pain and health-related quality of life among adults with arthritis: a large population-based cross-sectional study.Arthritis research & therapy · 2025Article
- Article
- Metabolic syndrome and its effect on the outcomes of rheumatoid arthritis in a multi-ethnic cohort in Singapore.Clinical rheumatology · 2022Article
- Functional coding haplotypes and machine-learning feature elimination identifies predictors of Methotrexate Response in Rheumatoid Arthritis patients.EBioMedicine · 2022Article
- Effects of illness perceptions on health-related quality of life in patients with rheumatoid arthritis in China.Health and quality of life outcomes · 2021Article
- Illness cognition and depression among patients with coronary heart disease.Belitung nursing journal · 2021Article
- Peripheral neuropathy and health-related quality of life in patients with primary Sjögren's syndrome: a preliminary report.Rheumatology international · 2020Observational
- Are extra-spinal symptoms associated with quality of life in patients with axial spondyloarthritis? A 1-year follow-up study.Clinical rheumatology · 2019Article
- Irritable Bowel Syndrome: Patient-Provider Interaction and Patient Education.Journal of clinical medicine · 2018Review
- Disease activity, resilience and health-related quality of life in Chinese patients with rheumatoid arthritis: a multi-center, cross-sectional study.Health and quality of life outcomes · 2017Article
- Psychometric properties of the Chinese version of Arthritis Self-Efficacy Scale-8 (ASES-8) in a rheumatoid arthritis population.Rheumatology international · 2017Article
- Sociodemographic factors associated with functional disability in outpatients with rheumatoid arthritis in Southwest China.Clinical rheumatology · 2015Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To investigate the association between helplessness, disability, and disease activity with health-related quality of life (HRQoL) in a multiethnic cohort of rheumatoid arthritis (RA) patients in Singapore. This cross-sectional study was conducted at Tan Tock Seng Hospital, Department of Rheumatology, Allergy and Immunology, from October 2010 to October 2011. All patients fulfilled the American College of Rheumatology 1987 criteria for RA. Socio-demographics, clinical, and patient-reported outcome (PRO) variables were collected. HRQoL outcomes were Short Form 36 (SF-36) physical and mental component summary (PCS and MCS) scores and Short Form 6 Dimensions (SF-6D) utilities. Stepwise multiple linear regression analyses were performed using HRQoL outcomes as dependent variables in separate models and with adjustment for helplessness (Rheumatology Attitudes Index, RAI), disability (Health Assessment Questionnaire, HAQ), and disease activity (Disease Activity in 28 joints) followed by socio-demographic, clinical, and PRO variables. Complete data were provided by 473 consenting subjects [mean (SD) age: 60.02 (11.04) years, 85 % female, 77 % Chinese]. After adjustment for all measured covariates, only RAI and HAQ scores remained significantly associated with SF-36 MCS (β: -0.9, p < 0.001; β: -7.0, p < 0.001) and SF-6D utilities (β: -0.005, p < 0.001; β: -0.081, p < 0.001), respectively, while only HAQ scores were significantly associated with SF-36 PCS (β: -7.7, p < 0.001). Interventions to address the sense of helplessness and to prevent or reduce disability could improve HRQoL of RA patients.
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