ArticleJournal of human hypertension2014
Differential gene expression of bradykinin receptors 1 and 2 in peripheral monocytes from patients with essential hypertension.
Article in Journal of human hypertension, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- The Role of Bradykinin Receptors in Hereditary Angioedema Due to C1-Inhibitor Deficiency.International journal of molecular sciences · 2022Article
- Associations Between Plasma Kinin B1 Receptor Levels and the Presence and Severity of Coronary Artery Disease.Journal of atherosclerosis and thrombosis · 2021Article
- Roles of Immune Cells in Hereditary Angioedema.Clinical reviews in allergy & immunology · 2021Review
- Kinin B1 Receptor Mediates Renal Injury and Remodeling in Hypertension.Frontiers in medicine · 2021Article
- Ethanolic Extract ofMolecules (Basel, Switzerland) · 2020Article
- MicroRNA-1253 Regulation of WASF2 (WAVE2) and its Relevance to Racial Health Disparities.Genes · 2020Article
- Kinin B1 Receptor Promotes Neurogenic Hypertension Through Activation of Centrally Mediated Mechanisms.Hypertension (Dallas, Tex. : 1979) · 2017Article
- MicroRNAs in the miR-17 and miR-15 families are downregulated in chronic kidney disease with hypertension.PloS one · 2017Article
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bradykinin participates in various hypertensive processes, exerted via its type 1 and type 2 receptors (BKR1 and BKR2). The aim of the study was to investigate BKR1 and BK2R gene expression in peripheral monocytes in patients with essential hypertension compared with healthy individuals. Seventeen hypertensive patients (9 males, age 56 ± 7 years) and 12 healthy individuals (7 males, age 55 ± 6) participated. Mononuclear cells isolated using anti-CD14+ antibodies and mRNAs of BKR1 and BKR2 were estimated by real-time quantitative reverse transcription-PCR. Both BKR1 and BKR2 showed significantly upregulated gene expression in the group of hypertensive patients. Specifically, BKR1 gene expression was 142.1 ± 42.2 in hypertensives versus 20.2 ± 8 in controls (P = 0.024) and BKR2 was 1222.2 ± 361.6 in hypertensives versus 259.5 ± 99.1 in controls (P = 0.038). Antihypertensive treatment resulted in a decrease in BKR1 (from 142.1 ± 42.2 to 55.2 ± 17.1, P = 0.065) and in BKR2 (from 1222.2 ± 361.6 to 256.8 ± 81.8, P = 0.014) gene expression. BKR1 and BKR2 gene expression on peripheral monocytes is upregulated in essential hypertension. This may lead to functional changes in monocytes and contribute to the development of target organ damage in hypertensive patients.
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