ArticleJAMA dermatology2014
Thymic stromal lymphopoietin variation, filaggrin loss of function, and the persistence of atopic dermatitis.
Article in JAMA dermatology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Biomarkers associated with the development of comorbidities in patients with atopic dermatitis: A systematic review.Allergy · 2023Pooled it
- Basophils promote innate lymphoid cell responses in inflamed skin.Journal of immunology (Baltimore, Md. : 1950) · 2014Trial
- Serum nuclear alarmins associate with IgE-mediated food sensitization, but have no role in effector response to food challenge.Pediatric research · 2026Article
- Skin Predictive Biomarkers for the Development of Atopic Dermatitis and Food Allergy in Infants.Allergy, asthma & immunology research · 2024Review
- Genetic and Immunological Pathogenesis of Atopic Dermatitis.The Journal of investigative dermatology · 2024Review
- Ethnic and Racial Disparities in Clinical Manifestations of Atopic Dermatitis.Archives of internal medicine research · 2024Article
- Overview of Atopic Dermatitis in Different Ethnic Groups.Journal of clinical medicine · 2023Review
- Combination of FLG mutations and SNP of TSLP (rs1898671) influence on atopic dermatitis occurrence.Postepy dermatologii i alergologii · 2022Article
- TSLP disease-associated genetic variants combined with airway TSLP expression influence asthma risk.The Journal of allergy and clinical immunology · 2022Article
- Genetic/Environmental Contributions and Immune Dysregulation in Children with Atopic Dermatitis.Journal of asthma and allergy · 2022Review
- Stem Cells from Human Exfoliated Deciduous Teeth Attenuate Atopic Dermatitis Symptoms in Mice through Modulating Immune Balance and Skin Barrier Function.Mediators of inflammation · 2022Article
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- Thymic stromal lymphopoietin, skin barrier dysfunction, and the atopic march.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2021Review
- HLA Class I Polymorphisms Influencing Both Peptide Binding and KIR Interactions Are Associated with Remission among Children with Atopic Dermatitis: A Longitudinal Study.Journal of immunology (Baltimore, Md. : 1950) · 2021Article
- TSLP and IL-7R Variants Are Associated with Persistent Atopic Dermatitis.The Journal of investigative dermatology · 2021Article
- Identifying Phenotypes of Atopic Dermatitis in a Longitudinal United States Cohort Using Unbiased Statistical Clustering.The Journal of investigative dermatology · 2020Article
- Association between fine mapping thymic stromal lymphopoietin and atopic dermatitis onset and persistence.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2019Article
- Asthma and Food Allergy: Which Risks?Medicina (Kaunas, Lithuania) · 2019Review
- Childhood atopic dermatitis: current developments, treatment approaches, and future expectationsTurkish journal of medical sciences · 2019Article
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7 authors.
Funding
Abstract
importanceAtopic dermatitis (AD) is a common chronic illness of childhood.
objectiveTo evaluate the association between thymic stromal lymphopoietin (TSLP) variation and the persistence of skin symptoms of AD. DESIGN, SETTING, AND
participantsA prospective cohort study was conducted in the general community. Participants included 796 children enrolled in the Pediatric Eczema Elective Registry. EXPOSURE Evaluation of TSLP variation. MAIN OUTCOMES AND MEASURES: Self-reported outcome of whether a child's skin had no symptoms of AD and required no medications for 6 months at 6-month intervals.
resultsWe evaluated 14 variants of TSLP. The variant rs1898671 was significantly associated with the outcome in white children (P = .01). As measured by overlapping CIs, similar odds ratios (ORs) were noted among whites (OR, 1.72; 95% CI, 1.11-2.66) and African Americans (1.33; 0.52-3.45). Further within the subcohort of individuals with a filaggrin protein (FLG) loss-of-function mutation, those with TSLP variation were more likely to have less-persistent disease (OR, 4.92; 95% CI, 2.04-11.86). CONCLUSIONS AND RELEVANCE: The TSLP variation is associated with less persistent AD. Therefore, TSLP may be a potential therapeutic target for the treatment of AD, especially in individuals with diminished barrier function due to FLG mutations. This is an attractive hypothesis that can be tested in clinical trials.
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