ArticleVirchows Archiv. A, Pathological anatomy and histopathology1987
Identification of the conserved, conformation-dependent cytokeratin epitope recognized by monoclonal antibody (lu-5).
Article in Virchows Archiv. A, Pathological anatomy and histopathology, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed.
- Review
- The binding of plakoglobin to desmosomal cadherins: patterns of binding sites and topogenic potential.The Journal of cell biology · 1996Article
- Cytokeratin expression in bovine corpora lutea.Histochemistry and cell biology · 1995Article
- Identification of amino acid sequence motifs in desmocollin, a desmosomal glycoprotein, that are required for plakoglobin binding and plaque formation.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- Identification of the plakoglobin-binding domain in desmoglein and its role in plaque assembly and intermediate filament anchorage.The Journal of cell biology · 1994Article
- An immunohistochemical and prognostic analysis of cytokeratin expression in malignant uveal melanoma.The American journal of pathology · 1992Article
- Intermediate filaments formed de novo from tail-less cytokeratins in the cytoplasm and in the nucleus.The Journal of cell biology · 1991Article
- Comparison of commercially available cytokeratin antibodies in normal and neoplastic adult epithelial and non-epithelial tissues.Journal of clinical pathology · 1991Article
- Neuronal and glial properties of a murine transgenic retinoblastoma model.The American journal of pathology · 1991Article
- Bronchial neuroendocrine (carcinoid) tumor causing unilateral left-sided carcinoid heart disease.Klinische Wochenschrift · 1991Article
- Identification of protein IT of the intestinal cytoskeleton as a novel type I cytokeratin with unusual properties and expression patterns.The Journal of cell biology · 1990Article
- Cytokeratin-immunoreactive cells of human lymph nodes and spleen in normal and pathological conditions. An immunocytochemical study.Virchows Archiv. A, Pathological anatomy and histopathology · 1990Article
- Cell type heterogeneity of intermediate filament expression in epithelia of the human pituitary gland.Histochemistry · 1989Article
- Epithelial markers in synovial sarcoma. An immunohistochemical study on paraffin embedded tissues.Virchows Archiv. A, Pathological anatomy and histopathology · 1989Article
- Cytoskeletons of retinal pigment epithelial cells: interspecies differences of expression patterns indicate independence of cell function from the specific complement of cytoskeletal proteins.Cell and tissue research · 1988Article
- Glial fibrillary acidic protein immunoreactivity in human respiratory tract cartilages and pulmonary chondromatous hamartomas.The American journal of pathology · 1988Article
- Organization of desmosomal plaque proteins in cells growing at low calcium concentrations.The Journal of cell biology · 1988Article
- Expression of simple epithelial type cytokeratins in stratified epithelia as detected by immunolocalization and hybridization in situ.The Journal of cell biology · 1988Article
- Coexpression of cytokeratins and vimentin in common epithelial tumours of the ovary: an immunocytochemical study of eighty-three cases.Virchows Archiv. A, Pathological anatomy and histopathology · 1988Article
- Analysis of cytokeratin domains by cloning and expression of intact and deleted polypeptides in Escherichia coli.The EMBO journal · 1987Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The epitope recognized by the murine monoclonal antibody (mAB lu-5) recently described as a formaldehyde-resistant, "pan-epithelial marker" of great value in tumour diagnosis is located on the surface of cytokeratin filaments. It has been preserved during vertebrate evolution from amphibia to man. As this epitope is not reactive after SDS-polyacrylamide gel electrophoresis (SDS-PAGE), the epitope-bearing protein has been identified by a dot-blot antibody binding assay, using purified proteins in which the epitope is reconstituted. We show that the epitope is present in most cytokeratin polypeptides of both the acidic (type I) and basic (type II) subfamily but does not occur in other cytoskeletal proteins. The location of this widespread epitope is discussed with respect to homologies of amino acid sequences of cytokeratins and their conformations.
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