ArticleBMJ open2014
Disease manifestations of Helicobacter pylori infection in Arctic Canada: using epidemiology to address community concerns.
Article in BMJ open, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Native and Indigenous Populations and Gastric Cancer: A Worldwide Review.International journal of environmental research and public health · 2022Pooled it
- ACG Clinical Guideline: Treatment of Helicobacter pylori Infection.The American journal of gastroenterology · 2017Guideline
- Increasing our knowledge about the epidemiology ofInternational journal of circumpolar health · 2024Article
- Changes in Gastric Pathology afterCancers · 2023Article
- Article
- Shifting paradigm from biomedical to decolonised methods in Inuit public health research in Canada: a scoping review.BMJ global health · 2022Article
- Prevalence of H. pylori among patients undergoing coronary angiography (The HP-DAPT prevalence study).Scientific reports · 2022Observational
- Community-driven research in the canadian arctic: dietary exposure to methylmercury and gastric health outcomes.International journal of circumpolar health · 2021Article
- The Prevalence ofJournal of clinical medicine research · 2020Article
- Antibiotic dispensation rates among participants in community-driven health research projects in Arctic Canada.BMC public health · 2019Article
- Burden of disease from Helicobacter pylori infection in western Canadian Arctic communities.BMC public health · 2019Article
- Gastric Cancer in Northern Canadian Populations: A Focus on Cardia and Non-Cardia Subsites.Cancers · 2019Article
- H. pylori-associated pathologic findings among Alaska native patients.International journal of circumpolar health · 2018Article
- Epidemiological and Clinical-Pathological Aspects ofGastroenterology research and practice · 2018Article
- Cancer mortality in Yukon 1999-2013: elevated mortality rates and a unique cancer profile.International journal of circumpolar health · 2017Article
- Complete Genome Sequences of Two Helicobacter pylori Strains from a Canadian Arctic Aboriginal Community.Genome announcements · 2015Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesHelicobacter pylori infection, linked to gastric cancer, is responsible for a large worldwide disease burden. H pylori prevalence and gastric cancer rates are elevated among indigenous Arctic communities, but implementation of prevention strategies is hampered by insufficient information. Some communities in northern Canada have advocated for H pylori prevention research. As a first step, community-driven research was undertaken to describe the H pylori-associated disease burden in concerned communities.
designParticipants in this cross-sectional study completed a clinical interview and gastroscopy with gastric biopsies taken for histopathological examination in February 2008.
settingStudy procedures were carried out at the health centre in Aklavik, Northwest Territories, Canada (population ∼600).
participantsAll residents of Aklavik were invited to complete a clinical interview and gastroscopy; 194 (58% female participants; 91% Aboriginal; age range 10-80 years) completed gastroscopy and had gastric biopsies taken. PRIMARY AND SECONDARY OUTCOME MEASURES: This analysis estimates the prevalence of gastric abnormalities detected by endoscopy and histopathology, and associations of demographic and clinical variables with H pylori prevalence.
resultsAmong 194 participants with evaluable gastric biopsies, 66% were H pylori-positive on histology. Among H pylori-positive participants, prevalence was 94% for acute gastritis, 100% for chronic gastritis, 21% for gastric atrophy and 11% for intestinal metaplasia of the gastric mucosa, while chronic inflammation severity was mild in 9%, moderate in 47% and severe in 43%. In a multivariable model, H pylori prevalence was inversely associated with previous gastroscopy, previous H pylori therapy and aspirin use, and was positively associated with alcohol consumption.
conclusionsIn this population, H pylori-associated gastric histopathology shows a pattern compatible with elevated risk of gastric cancer. These findings demonstrate that local concern about health risks from H pylori is warranted and provide an example of how epidemiological research can address health priorities identified by communities.
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