ArticleJournal of diabetes and metabolic disorders2014
Metals in the pathogenesis of type 2 diabetes.
Article in Journal of diabetes and metabolic disorders, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
What it found
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Who cites it
52 citing papers in PubMed, 133 citations in OpenAlex.
- Trace Elements in the Pancreas: From Physiological Homeostasis to the Pathogenesis of Diabetes, Pancreatitis, and Cancer-A Review.Life (Basel, Switzerland) · 2026Review
- Toxic Effects of Acute Water Selenium Exposure onAnimals : an open access journal from MDPI · 2025Article
- Concentrations of trace metals in serum: Implications for type 2 diabetes mellitus and gender difference.Environmental analysis, health and toxicology · 2025Article
- Copper Dyshomeostasis and Diabetic Complications: Chelation Strategies for Management.Mini reviews in medicinal chemistry · 2025Review
- The role of metal ion metabolism in the pathogenesis of diabetes and associated complications.Frontiers in endocrinology · 2025Review
- Association of heavy metals and bio-elements blood level with metabolic syndrome: a systematic review and meta-analysis of observational studies.Journal of diabetes and metabolic disorders · 2024Review
- Association Between Zinc Status and Insulin Resistance/Sensitivity Check Indexes in Gestational Diabetes Mellitus.International journal of molecular sciences · 2024Article
- The Role of Endocrine Disruption Chemical-Regulated Aryl Hydrocarbon Receptor Activity in the Pathogenesis of Pancreatic Diseases and Cancer.International journal of molecular sciences · 2024Review
- Mixture effects of trace element levels on cardiovascular diseases and type 2 diabetes risk in adults using G-computation analysis.Scientific reports · 2024Article
- Associations between metals and metabolomic profiles related to diabetes among adults in a rural region.Environmental research · 2024Article
- Environmental exposure to lead and cadmium are associated with triglyceride glucose index.Scientific reports · 2024Article
- Impact of lowering the US maximum contaminant level on arsenic exposure: Differences by race, region, and water arsenic in NHANES 2003-2014.Environmental pollution (Barking, Essex : 1987) · 2023Article
- Relationships Between Maternal Selected Metals (Cu, Mg, Zn and Fe), Thyroid Function and Blood Glucose Levels During Pregnancy.Biological trace element research · 2023Article
- SXRF for Studying the Distribution of Trace Metals in the Pancreas and Liver.Antioxidants (Basel, Switzerland) · 2023Article
- Review
- Combined exposure to multiple essential elements and cadmium at early pregnancy on gestational diabetes mellitus: a prospective cohort study.Frontiers in nutrition · 2023Article
- An Overview of Herbal-Based Antidiabetic Drug Delivery Systems: Focus on Lipid- and Inorganic-Based Nanoformulations.Pharmaceutics · 2022Review
- Long-term association of serum selenium levels and the diabetes risk: Findings from a case-control study nested in the prospective Jinchang Cohort.The Science of the total environment · 2022Article
- Towards the Pharmacological Validation and Phytochemical Profiling of the Decoction and Maceration ofMolecules (Basel, Switzerland) · 2022Article
- Association between heavy metals and metabolic syndrome in drinking water and surface soil: case-control study in Iran.Environmental science and pollution research international · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Minerals are one of the components of food, though they are not synthesized in the body but they are essential for optimal health. Several essential metals are required for the proper functioning of many enzymes, transcriptional factors and proteins important in various biochemical pathways. For example Zn, Mg and Mn are cofactors of hundreds of enzymes, and Zn is involved in the synthesis and secretion of insulin from the pancreatic beta-cells. Similarly, Cr enhances the insulin receptor activity on target tissues, especially in muscle cells. Insulin is the key hormone required to maintain the blood glucose level in normal range. In case of insulin deficiency or resistance, blood glucose concentration exceeds the upper limit of the normal range of 126 mg/dl. Persistent increase of blood serum glucose level leads to overt chronic hyperglycemia, which is a major clinical symptom of diabetes mellitus. Poor glycemic control and diabetes alters the levels of essential trace elements such as Zn, Mg, Mn, Cr, Fe etc. by increasing urinary excretion and their concomitant decrease in the blood. Hence, the main purpose of this review is to discuss the important roles of essential trace elements in normal homeostasis and physiological functioning. Moreover, perturbation of essential trace elements is also discussed in perspective of type 2 diabetes pathobiology.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.