ArticleMalaria journal2014
Genetic diversity of Plasmodium vivax population in Anhui province of China.
Article in Malaria journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Genetic Diversity ofTropical medicine and infectious disease · 2023Article
- Prevalence of antifolate drug resistance markers in Plasmodium vivax in China.Frontiers of medicine · 2022Article
- Analysis of polymorphisms in the circumsporozoite protein gene of Plasmodium vivax isolates from Henan Province, China.Malaria journal · 2018Article
- Genetic diversity of Plasmodium Vivax revealed by the merozoite surface protein-1 icb5-6 fragment.Infectious diseases of poverty · 2017Article
- An outbreak of locally acquired Plasmodium vivax malaria among migrant workers in Oman.Parasite (Paris, France) · 2017Article
- Geographic distribution of amino acid mutations in DHFR and DHPS in Plasmodium vivax isolates from Lao PDR, India and Colombia.Malaria journal · 2016Article
- Genetic diversity of Plasmodium vivax population before elimination of malaria in Hainan Province, China.Malaria journal · 2015Article
- Genetic diversity of Plasmodium Vivax in South of Iran: A cross-sectional study.Journal of medicine and life · 2015Article
- The Plasmodium vivax merozoite surface protein 3β sequence reveals contrasting parasite populations in southern and northwestern Thailand.PLoS neglected tropical diseases · 2014Article
- Molecular surveillance of pvdhfr, pvdhps, and pvmdr-1 mutations in Plasmodium vivax isolates from Yunnan and Anhui provinces of China.Malaria journal · 2014Article
- Genetic diversity and population structure of Plasmodium vivax in Central China.Malaria journal · 2014Article
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10 authors.
Funding
Abstract
backgroundAlthough the numbers of malaria cases in China have been declining in recent years, outbreaks of Plasmodium vivax malaria were still being reported in rural areas south of the Yellow River. To better understand the transmission dynamics of P. vivax parasites in China, the extent of genetic diversity of P. vivax populations circulating in Bozhou of Anhui province of China were investigated using three polymorphic genetic markers: merozoite surface proteins 1 and 3α (pvmsp-1 and pvmsp-3α) and circumsporozoite protein (pvcsp).
methodsForty-five P. vivax clinical isolates from Bouzhou of Anhui province were collected from 2009 to 2010 and were analysed using PCR/RFLP or DNA sequencing.
resultsSeven and six distinct allelic variants were identified using PCR/RFLP analysis of pvmsp-3α with HhaI and AluI, respectively. DNA sequence analysis of pvmsp-1 (variable block 5) revealed that there were Sal-I and recombinant types but not Belem type, and seven distinct allelic variants in pvmsp-1 were detected, with recombinant subtype 2 (R2) being predominant (66.7%). All the isolates carried pvcsp with VK210 type but not VK247 or P. vivax-like types in the samples. Sequence analysis of pvcsp gene revealed 12 distinct allelic variants, with VK210-1 being predominant (41.5%).
conclusionsThe present data indicate that there is some degree of genetic diversity among P. vivax populations in Anhui province of China. The genetic data obtained may assist in the surveillance of P. vivax infection in endemic areas or in tracking potential future disease outbreak.
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