ArticleJournal of the American Chemical Society2014
A 3D-printed high power nuclear spin polarizer.
Article in Journal of the American Chemical Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed.
- Continuous Delivery of Hyperpolarized Xenon-129 Gas Using a "Stopped-Flow" Clinical-Scale Cryogen-Free Hyperpolarizer.Analytical chemistry · 2025Article
- Low-Cost Purpose-Built Ultra-Low-Field NMR Spectrometer.Analytical chemistry · 2024Article
- Spin Hyperpolarization in Modern Magnetic Resonance.Chemical reviews · 2023Review
- Pilot Quality-Assurance Study of a Third-Generation Batch-Mode Clinical-Scale Automated Xenon-129 Hyperpolarizer.Molecules (Basel, Switzerland) · 2022Article
- Enabling Clinical Technologies for HyperpolarizedAngewandte Chemie (International ed. in English) · 2021Review
- Heterogeneous Parahydrogen-Induced Polarization of Diethyl Ether for Magnetic Resonance Imaging Applications.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
- A semi-empirical model to optimize continuous-flow hyperpolarizedJournal of magnetic resonance (San Diego, Calif. : 1997) · 2020Article
- High Xe density, high photon flux, stopped-flow spin-exchange optical pumping: Simulations versus experiments.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2020Article
- Characterization of 3-Dimensional Printing and Casting Materials for use in Magnetic Resonance Imaging Phantoms at 3 T.Journal of research of the National Institute of Standards and Technology · 2020Article
- Clinical-Scale Batch-Mode Production of Hyperpolarized Propane Gas for MRI.Analytical chemistry · 2019Article
- Heterogeneous Parahydrogen Pairwise Addition to Cyclopropane.Chemphyschem : a European journal of chemical physics and physical chemistry · 2018Article
- Parahydrogen-Based Hyperpolarization for Biomedicine.Angewandte Chemie (International ed. in English) · 2018Review
- Additive manufacturing of three-dimensional (3D) microfluidic-based microelectromechanical systems (MEMS) for acoustofluidic applications.Lab on a chip · 2018Article
- A pulse programmable parahydrogen polarizer using a tunable electromagnet and dual channel NMR spectrometer.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2017Article
- 3D Printed UV-Visible Cuvette Adapter for Low-Cost and Versatile Spectroscopic Experiments.ACS omega · 2017Article
- High-resolution hyperpolarized in vivo metabolicJournal of magnetic resonance (San Diego, Calif. : 1997) · 2017Article
- Magnetic resonance imaging with hyperpolarized agents: methods and applications.Physics in medicine and biology · 2017Review
- Feasibility, tolerability and safety of pediatric hyperpolarizedPediatric radiology · 2016Article
- Open-Source Automated Parahydrogen Hyperpolarizer for Molecular Imaging Using (13)C Metabolic Contrast Agents.Analytical chemistry · 2016Article
- Molecular hydrogen and catalytic combustion in the production of hyperpolarized 83Kr and 129Xe MRI contrast agents.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Three-dimensional printing with high-temperature plastic is used to enable spin exchange optical pumping (SEOP) and hyperpolarization of xenon-129 gas. The use of 3D printed structures increases the simplicity of integration of the following key components with a variable temperature SEOP probe: (i) in situ NMR circuit operating at 84 kHz (Larmor frequencies of (129)Xe and (1)H nuclear spins), (ii) <0.3 nm narrowed 200 W laser source, (iii) in situ high-resolution near-IR spectroscopy, (iv) thermoelectric temperature control, (v) retroreflection optics, and (vi) optomechanical alignment system. The rapid prototyping endowed by 3D printing dramatically reduces production time and expenses while allowing reproducibility and integration of "off-the-shelf" components and enables the concept of printing on demand. The utility of this SEOP setup is demonstrated here to obtain near-unity (129)Xe polarization values in a 0.5 L optical pumping cell, including ∼74 ± 7% at 1000 Torr xenon partial pressure, a record value at such high Xe density. Values for the (129)Xe polarization exponential build-up rate [(3.63 ± 0.15) × 10(-2) min(-1)] and in-cell (129)Xe spin-lattice relaxation time (T1 = 2.19 ± 0.06 h) for 1000 Torr Xe were in excellent agreement with the ratio of the gas-phase polarizations for (129)Xe and Rb (PRb ∼ 96%). Hyperpolarization-enhanced (129)Xe gas imaging was demonstrated with a spherical phantom following automated gas transfer from the polarizer. Taken together, these results support the development of a wide range of chemical, biochemical, material science, and biomedical applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.