ArticleJournal of the American Chemical Society2014
Superselective targeting using multivalent polymers.
Article in Journal of the American Chemical Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed.
- Avidity-by-design: spatial control of T7 peptide presentation on polymersomes dictates blood-brain barrier transport fate.Drug delivery and translational research · 2026Article
- Biomimetic peptide self-assembly: interfacing with biomacromolecules to regulate cellular signaling.Experimental & molecular medicine · 2026Review
- From Single Ligand-Receptor Bond Strength to Collective Avidity: Mechanics-Guided Superselective Nanoparticle Adhesion to Biological Membranes.Langmuir : the ACS journal of surfaces and colloids · 2025Article
- Electrochemical Controlling of Double Microgel Layer Formation on an Electrode Surface via an Electrosensitive Inclusion Complex.ACS materials Au · 2025Article
- Enhanced Prostate-specific Membrane Antigen Targeting by Precision Control of DNA Scaffolded Nanoparticle Ligand Presentation.ACS nano · 2024Article
- Stereoselective Polymerization of 3,6-DisubstitutedACS macro letters · 2024Article
- Whole-genome detection using multivalent DNA-coated colloids.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Glycomimetics for the inhibition and modulation of lectins.Chemical Society reviews · 2023Review
- The Role of Receptor Uniformity in Multivalent Binding.JACS Au · 2023Article
- Determinants of Superselectivity─Practical Concepts for Application in Biology and Medicine.Accounts of chemical research · 2023Article
- A Review of Protein- and Peptide-Based Chemical Conjugates: Past, Present, and Future.Pharmaceutics · 2023Review
- Bimodal brush-functionalized nanoparticles selective to receptor surface density.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Amplification Free Detection of SARS-CoV-2 Using Multi-Valent Binding.ACS sensors · 2022Article
- Multivalent Pattern Recognition through Control of Nano-Spacing in Low-Valency Super-Selective Materials.Journal of the American Chemical Society · 2022Article
- Controlling Superselectivity of Multivalent Interactions with Cofactors and Competitors.Journal of the American Chemical Society · 2022Article
- A quartz crystal microbalance method to quantify the size of hyaluronan and other glycosaminoglycans on surfaces.Scientific reports · 2022Article
- Direct visualization of superselective colloid-surface binding mediated by multivalent interactions.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Hyaluronan and Its Receptors: Key Mediators of Immune Cell Entry and Trafficking in the Lymphatic System.Cells · 2021Review
- Multivalent Affinity Profiling: Direct Visualization of the Superselective Binding of Influenza Viruses.ACS nano · 2021Article
- Combinatorial entropy behaviour leads to range selective binding in ligand-receptor interactions.Nature communications · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Despite their importance for material and life sciences, multivalent interactions between polymers and surfaces remain poorly understood. Combining recent achievements of synthetic chemistry and surface characterization, we have developed a well-defined and highly specific model system based on host/guest interactions. We use this model to study the binding of hyaluronic acid functionalized with host molecules to tunable surfaces displaying different densities of guest molecules. Remarkably, we find that the surface density of bound polymer increases faster than linearly with the surface density of binding sites. Based on predictions from a simple analytical model, we propose that this superselective behavior arises from a combination of enthalpic and entropic effects upon binding of nanoobjects to surfaces, accentuated by the ability of polymer chains to interpenetrate.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.