ReviewFrontiers in pediatrics2013
New paradigms in the pathogenesis of otitis media in children.
Review in Frontiers in pediatrics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Metabolomic Profiling of Middle Ear Effusion Suggests a Predominant Influence of Age over Viscosity: An HR-MAS NMR Study.International journal of molecular sciences · 2025Article
- Host-Microbe Interactions in Healthy and CSOM-Affected Middle Ears.Microorganisms · 2025Article
- In Vivo Optical Characterization of Middle Ear Effusions and Biofilms During Otitis Media.Journal of the Association for Research in Otolaryngology : JARO · 2023Observational
- Effects of air pollution on emergency visits for acute otitis media among children: a case-crossover study in Chongqing, China.Frontiers in public health · 2023Article
- Ear microbiota and middle ear disease: a longitudinal pilot study of Aboriginal children in a remote south Australian setting.BMC microbiology · 2022Article
- Distribution and Antimicrobial Resistance Profiles of Bacterial Aetiologies of Childhood Otitis Media in Accra, Ghana.Microbiology insights · 2022Article
- Novel Antimicrobial Treatment Strategy Based on Drug Delivery Systems for Acute Otitis Media.Frontiers in pharmacology · 2021Review
- Role of Surfactant Protein D in Experimental Otitis Media.Journal of innate immunity · 2021Article
- Effects of Amniotic Membrane Extract on the Hyperplastic Response of the Middle Ear Mucosa in a Bacterially-Induced Otitis Media Rat Model: A Preliminary Study.Clinical and experimental otorhinolaryngology · 2020Article
- Optical Identification of Middle Ear Infection.Molecules (Basel, Switzerland) · 2020Review
- Immunization with a Biofilm-Disrupting NontypeablemSphere · 2020Article
- Bacterial Biofilm and its Role in the Pathogenesis of Disease.Antibiotics (Basel, Switzerland) · 2020Review
- Biofilm production by Haemophilus influenzae and Streptococcus pneumoniae isolated from the nasopharynx of children with acute otitis media.BMC infectious diseases · 2019Article
- Automated classification platform for the identification of otitis media using optical coherence tomography.NPJ digital medicine · 2019Article
- Age-Dependent Dissimilarity of the Nasopharyngeal and Middle Ear Microbiota in Children With Acute Otitis Media.Frontiers in genetics · 2019Article
- Recent Perspectives on Gene-Microbe Interactions Determining Predisposition to Otitis Media.Frontiers in genetics · 2019Review
- Article
- Noninvasive in vivo optical coherence tomography tracking of chronic otitis media in pediatric subjects after surgical intervention.Journal of biomedical optics · 2017Article
- Clinical translation of handheld optical coherence tomography: practical considerations and recent advancements.Journal of biomedical optics · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute otitis media (AOM) is a multifactorial disease with a significant socioeconomic impact. The pathogenesis of AOM is attributed to a variety of well-established internal and extrinsic factors. Recent evidence strongly points to bacterial biofilm formation as an important contributor to this disease entity. The nasopharynx is a likely reservoir for infection with subsequent seeding of pathogens to the middle ear via planktonic shedding. Various modalities have been used to directly detect biofilm formation in the middle ear mucosa of children with AOM. Further insights into this disease may lead to new strategies for prevention and treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.