ArticleFrontiers in pediatrics2013
Autonomic nervous system function following prenatal opiate exposure.
Article in Frontiers in pediatrics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- Effects of an attachment-based intervention on autonomic regulation among opioid-exposed infants.Developmental psychobiology · 2022Trial
- Modeling heart rate patterns to quantify neonatal opioid withdrawal syndrome.Pediatric research · 2026Article
- Postpartum depression and the moderating role of empathy on child physiological reactivity.Italian journal of pediatrics · 2025Observational
- Effects of prenatal opioid exposure on infant sympathetic and parasympathetic nervous system activity.Psychophysiology · 2024Article
- Article
- The Neonatal Withdrawal Assessment Tool (NWAT): pilot inter-rater reliability and content validity.Journal of perinatology : official journal of the California Perinatal Association · 2023Article
- A mini review of what matters in the management of NAS, is ESC the best care?Frontiers in pediatrics · 2023Review
- Neonatal heart rate variability: a contemporary scoping review of analysis methods and clinical applications.BMJ open · 2021Article
- Autonomic nervous system development and its impact on neuropsychiatric outcome.Pediatric research · 2019Review
- Early life stress and environmental influences on the neurodevelopment of children with prenatal opioid exposure.Neurobiology of stress · 2018Review
- The Epidemic of Neonatal Abstinence Syndrome, Historical References of Its' Origins, Assessment, and Management.Frontiers in pediatrics · 2018Review
- Simplification of the Finnegan Neonatal Abstinence Scoring System: retrospective study of two institutions in the USA.BMJ open · 2017Article
- Reconceptualizing non-pharmacologic approaches to Neonatal Abstinence Syndrome (NAS) and Neonatal Opioid Withdrawal Syndrome (NOWS): A theoretical and evidence-based approach.Neurotoxicology and teratologyReview
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In utero exposure to opiates may affect autonomic functioning of the fetus and newborn. We investigated heart rate variability (HRV) as a measure of autonomic stability in prenatal opiate-exposed neonates (n = 14) and in control term infants (n = 10). Electrocardiographic data during both non-nutritive and nutritive sucking were evaluated for RR intervals, heart rate (HR), standard deviation of the consecutive RR intervals (SDRR), standard deviation of the differences of consecutive RR intervals (SDDRR), and the power spectral densities in low and high frequency bands. In controls, mean HR increased significantly, 143-161 per min (p = 0.002), with a trend toward a decrease in RR intervals from non-nutritive to nutritive sucking; these measures did not change significantly among exposed infants. Compared to controls, exposed infants demonstrated significantly greater HRV or greater mean SDRR and SDDRR during non-nutritive period (p < 0.01), greater mean SDDRR during nutritive sucking (p = 0.02), and higher powers in the low and high frequency bands during nutritive feedings. Our findings suggest that prenatal opiate exposure may be associated with changes in autonomic nervous system (ANS) functioning involving both sympathetic and parasympathetic branches. Future studies are needed to examine the effects of prenatal opiate exposure on ANS function.
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Registered trials
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