ReviewFrontiers in pediatrics2013
Pathophysiology, management, and outcome of persistent pulmonary hypertension of the newborn: a clinical review.
Review in Frontiers in pediatrics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02940327 (A Feasibility Study to Consider the Relationship Between Markers of Red Cell Damage, Inflammation and the Recovery Process of Newborns Requiring Extracorporeal Membrane Oxygenation), which is not on this map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Feasibility Study to Consider the Relationship Between Markers of Red Cell Damage, Inflammation and the Recovery Process of Newborns Requiring Extracorporeal Membrane Oxygenation (ECMO) for Persistent Pulmonary Hypertension of the Newborn (PPHN): Mi-ECMO
Who cites it
20 citing papers in PubMed, 132 citations in OpenAlex.
- Clinical profile, survival outcomes, and predictors of mortality in neonates with persistent pulmonary hypertension: a follow-up study from Hawassa, Ethiopia.BMC pediatrics · 2026Article
- Meconium aspiration syndrome: a comprehensive review.Journal of perinatology : official journal of the California Perinatal Association · 2023Review
- Intravenous sildenafil for treatment of early pulmonary hypertension in preterm infants.Scientific reports · 2023Article
- Genome-wide association study identifies WWC2 as a possible locus associated with persistent pulmonary hypertension of the newborn in the Thai population.Translational pediatrics · 2023Article
- Low Apgar score and asphyxia complications at birth and risk of longer-term cardiovascular disease: a nationwide population-based study of term infants.The Lancet regional health. Europe · 2023Article
- The Efficacy and Safety of Pulmonary Vasodilators in Pediatric Pulmonary Hypertension (PH): A Systematic Review and Meta-analysis.Frontiers in pharmacology · 2021Article
- Getting an Early Start in Understanding Perinatal Asphyxia Impact on the Cardiovascular System.Frontiers in pediatrics · 2020Review
- The Off-Label Use of Inhaled Nitric Oxide as a Rescue Therapy in Neonates with Refractory Hypoxemic Respiratory Failure: Therapeutic Response and Risk Factors for Mortality.Journal of clinical medicine · 2019Article
- Comprehensive Evaluation of Right Heart Performance and Pulmonary Hemodynamics in Neonatal Pulmonary Hypertension : Evaluation of cardiopulmonary performance in neonatal pulmonary hypertension.Current treatment options in cardiovascular medicine · 2019Review
- Umbilical cord blood metabolomics reveal distinct signatures of dyslipidemia prior to bronchopulmonary dysplasia and pulmonary hypertension.American journal of physiology. Lung cellular and molecular physiology · 2018Article
- Application of Neonatologist Performed Echocardiography in the assessment and management of persistent pulmonary hypertension of the newborn.Pediatric research · 2018Review
- Mitochondrial Complex IV Subunit 4 Isoform 2 Is Essential for Acute Pulmonary Oxygen Sensing.Circulation research · 2017Article
- Treprostinil for persistent pulmonary hypertension of the newborn, with early onset sepsis in preterm infant: 2 Case reports.Medicine · 2017Article
- Nitric oxide in paediatric respiratory disorders: novel interventions to address associated vascular phenomena?Therapeutic advances in cardiovascular disease · 2016Review
- Nogo-B Receptor Modulates Pulmonary Artery Smooth Muscle Cell Function in Developing Lungs.American journal of respiratory cell and molecular biology · 2016Article
- Safety of Selective Serotonin Reuptake Inhibitors in Pregnancy: A Review of Current Evidence.CNS drugs · 2016Review
- Right ventricular echocardiographic indices predict poor outcomes in infants with persistent pulmonary hypertension of the newborn.European heart journal. Cardiovascular Imaging · 2015Article
- Mechanism by which nuclear factor-kappa beta (NF-kB) regulates ovine fetal pulmonary vascular smooth muscle cell proliferation.Molecular genetics and metabolism reports · 2015Article
- Antidepressant use late in pregnancy and risk of persistent pulmonary hypertension of the newborn.JAMA · 2015Article
- Diffuse lung disease of infancy: a pattern-based, algorithmic approach to histological diagnosis.Journal of clinical pathology · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Persistent Pulmonary Hypertension of the Newborn (PPHN) results from the failure of relaxation of the pulmonary vasculature at birth, leading to shunting of non-oxygenated blood from the pulmonary to the systemic circulation. More often, full term and near-term infants are affected, however it is not uncommon to see PPHN in preterm infants who have respiratory distress syndrome. In some infants pulmonary vascular remodeling is present at birth, pointing toward the prenatal onset of the disease process. Regardless of the etiology, PPHN should be diagnosed and treated as soon as possible to avoid hypoxia related short term and long-term morbidities. The mainstay therapy is the treatment of the underlying condition along with several promising therapeutic modalities such as oxygen supplementation, mechanical ventilation, nitric oxide, phosphodiesterase inhibitors, prostaglandins analogs, endothelin receptor antagonists, and extracorporeal membrane oxygenation. The optimal approach to the management of PPHN remains controversial. After discharge from the NICU, infants with PPHN warrant long-term follow up since they are at risk for neurodevelopmental disabilities and chronic health conditions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.