ArticlePhysiological reports2013
The human sodium-dependent ascorbic acid transporters SLC23A1 and SLC23A2 do not mediate ascorbic acid release in the proximal renal epithelial cell.
Article in Physiological reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 23 citations in OpenAlex.
- Effects of Dietary Vitamin C Supplementation on Vitamin C Synthesis, Transport, and Egg Deposition in Breeding Geese.Animals : an open access journal from MDPI · 2026Article
- Genome-wide association analysis of neutrophil granularity identifies CDK6 as a regulator of primary granules.iScience · 2025Article
- Exploring the Potential of Malvidin and Echiodinin as Probable Antileishmanial Agents Through In Silico Analysis and In Vitro Efficacy.Molecules (Basel, Switzerland) · 2025Article
- Antioxidative effects of molybdenum and its association with reduced prevalence of hyperuricemia in the adult population.PloS one · 2024Article
- Association between oxidative balance score and serum uric acid and hyperuricemia: a population-based study from the NHANES (2011-2018).Frontiers in endocrinology · 2024Article
- Composite Dietary Antioxidant Index Is Negatively Associated with Hyperuricemia in US Adults: An Analysis of NHANES 2007-2018.International journal of endocrinology · 2023Article
- Abnormal urinary loss of vitamin C in diabetes: prevalence and clinical characteristics of a vitamin C renal leak.The American journal of clinical nutrition · 2022Article
- Review
- Enhanced Resorption of Liposomal Packed Vitamin C Monitored by Ultrasound.Journal of clinical medicine · 2020Article
- The Pharmacokinetics of Vitamin C.Nutrients · 2019Review
- The Association Between Ascorbate and the Hypoxia-Inducible Factors in Human Renal Cell Carcinoma Requires a Functional Von Hippel-Lindau Protein.Frontiers in oncology · 2018Article
- Protective Role for Antioxidants in Acute Kidney Disease.Nutrients · 2017Review
- Temporo-spacial microanatomical distribution of the murine sodium-dependent ascorbic acid transporters Slc23a1 and Slc23a2 in the kidney throughout development.Biochemistry and cell biology = Biochimie et biologie cellulaire · 2017Article
- Vitamin C Transporters in Cancer: Current Understanding and Gaps in Knowledge.Frontiers in oncology · 2017Review
- Vitamin C: the known and the unknown and Goldilocks.Oral diseases · 2016Review
- Understanding the aristolochic acid toxicities in rat kidneys with regulatory networks.IET systems biology · 2015Article
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Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
Abstract
Sodium-dependent ascorbic acid membrane transporters SLC23A1 and SLC23A2 mediate ascorbic acid (vitamin C) transport into cells. However, it is unknown how ascorbic acid undergoes cellular release, or efflux. We hypothesized that SLC23A1 and SLC23A2 could serve a dual role, mediating ascorbic acid cellular efflux as well as uptake. Renal reabsorption is required for maintaining systemic vitamin C concentrations. Because efflux from nephron cells is necessary for reabsorption, we studied whether SLC23A1 and SLC23A2 mediate efflux of ascorbic acid in the human renal nephron. We found high gene expression of SLC23A1 but no expression of SLC23A2 in the proximal convoluted and straight tubules of humans. These data rule out SLC23A2 as the ascorbic acid release protein in the renal proximal tubular epithelia cell. We utilized a novel dual transporter-based Xenopus laevis oocyte system to investigate the function of the SLC23A1 protein, and found that no ascorbate release was mediated by SLC23A1. These findings were confirmed in mammalian cells overexpressing SLC23A1. Taken together, the data for SLC23A1 show that it too does not have a role in cellular release of ascorbic acid across the basolateral membrane of the proximal tubular epithelial cell, and that SLC23A1 alone is responsible for ascorbic acid uptake across the apical membrane. These findings reiterate the physiological importance of proper functioning of SLC23A1 in maintaining vitamin C levels for health and disease prevention. The ascorbate efflux mechanism in the proximal tubule of the kidney remains to be characterized.
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Registered trials
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