ReviewFrontiers in immunology2013
Sensing microbial RNA in the cytosol.
Review in Frontiers in immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 44 citations in OpenAlex.
- Mitochondrial RNA cytosolic leakage drives the SASP.Nature communications · 2025Article
- A Novel Immune-Related Three-Gene Signature and Immune Infiltration Insights in Psoriasis and Chronic Kidney Disease.Clinical, cosmetic and investigational dermatology · 2025Article
- Understanding nucleic acid sensing and its therapeutic applications.Experimental & molecular medicine · 2023Review
- TheInternational journal of molecular sciences · 2023Article
- The Immunogenetics of Psoriasis.Advances in experimental medicine and biology · 2022Article
- Porcine RIG-I and MDA5 Signaling CARD Domains Exert Similar Antiviral Function Against Different Viruses.Frontiers in microbiology · 2021Article
- Effect of ORF7 of SARS-CoV-2 on the Chemotaxis of Monocytes and Neutrophils In Vitro.Disease markers · 2021Article
- Analysis of Porcine RIG-I Like Receptors Revealed the Positive Regulation of RIG-I and MDA5 by LGP2.Frontiers in immunology · 2021Article
- A MicroRNA Network ControlsmBio · 2020Article
- Adeno-associated viral vector-mediated immune responses: Understanding barriers to gene delivery.Pharmacology & therapeutics · 2020Review
- Review
- TLR7 and TLR3 SenseFrontiers in immunology · 2017Article
- Sequence-Specific Sensing of Nucleic Acids.Trends in immunology · 2017Review
- Prediction of Immunomodulatory potential of an RNA sequence for designing non-toxic siRNAs and RNA-based vaccine adjuvants.Scientific reports · 2016Article
- Article
- The immunogenetics of Psoriasis: A comprehensive review.Journal of autoimmunity · 2015Review
- Effects of ionizing radiation on retinoic acid-inducible gene-I-like receptors.Biomedical reports · 2015Article
- Innate receptors and cellular defense against pulmonary infections.Journal of immunology (Baltimore, Md. : 1950) · 2014Review
- Optimization of the immunogenicity of a DNA vaccine encoding a bacterial outer membrane lipoprotein.Molecular biotechnology · 2014Article
- Ionizing radiation affects the expression of Toll-like receptors 2 and 4 in human monocytic cells through c-Jun N-terminal kinase activation.Journal of radiation research · 2014Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The innate immune system faces the difficult task of keeping a fine balance between sensitive detection of microbial presence and avoidance of autoimmunity. To this aim, key mechanisms of innate responses rely on isolation of pathogens in specialized subcellular compartments, or sensing of specific microbial patterns absent from the host. Efficient detection of foreign RNA in the cytosol requires an additional layer of complexity from the immune system. In this particular case, innate sensors should be able to distinguish self and non-self molecules that share several similar properties. In this review, we discuss this interplay between cytosolic pattern recognition receptors and the microbial RNA they detect. We describe how microbial RNAs gain access to the cytosol, which receptors they activate and counter-strategies developed by microorganisms to avoid this response.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.