Evidence map›Paper›PMID 24399951›Full record

ReviewFrontiers in human neuroscience2013

Recovery after brain injury: mechanisms and principles.

Randolph J Nudo

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in human neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04824482 (GAIT Recovery in Patients aFter Acute Ischemic STroke), which is not on this map. Cited by 237 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
237citing papers in PubMed, 13 pooled it
28.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04824482 narecruitingnot on this mapstarted 2020, after this paper: background citation

GAIT Recovery in Patients aFter Acute Ischemic STroke: A Randomized Comparison of Robot-assisted and Therapist-assisted Gait Training on a Treadmill.

TypeinterventionalSponsorUniversity Hospital OlomoucRan2020 to 2026Enrolled120ConditionsIschemic StrokeArmsRobot-assisted treadmill gait training (RTGT), Therapist-assisted treadmill gait training (TTGT)
3 · Its place in the literature

Who cites it

237 citing papers in PubMed, 13 syntheses or guidelines pooled it, 494 citations in OpenAlex.

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177 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Randolph J NudoDepartment of Molecular and Integrative Physiology, Landon Center on Aging, University of Kansas Medical Center Kansas, KS, USA.
University of Kansas Medical Center · US

Funding

Reorganization of motor cortex following brain injuryR37NS030853 · NINDS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI NUDO, RANDOLPH J. · 2008 to 2014
$4.6M
NINDS NIH HHS R37 NS030853
6 · The paper itself

Abstract

The past 20 years have represented an important period in the development of principles underlying neuroplasticity, especially as they apply to recovery from neurological injury. It is now generally accepted that acquired brain injuries, such as occur in stroke or trauma, initiate a cascade of regenerative events that last for at least several weeks, if not months. Many investigators have pointed out striking parallels between post-injury plasticity and the molecular and cellular events that take place during normal brain development. As evidence for the principles and mechanisms underlying post-injury neuroplasticity has been gleaned from both animal models and human populations, novel approaches to therapeutic intervention have been proposed. One important theme has persisted as the sophistication of clinicians and scientists in their knowledge of neuroplasticity mechanisms has grown: behavioral experience is the most potent modulator of brain plasticity. While there is substantial evidence for this principle in normal, healthy brains, the injured brain is particularly malleable. Based on the quantity and quality of motor experience, the brain can be reshaped after injury in either adaptive or maladaptive ways. This paper reviews selected studies that have demonstrated the neurophysiological and neuroanatomical changes that are triggered by motor experience, by injury, and the interaction of these processes. In addition, recent studies using new and elegant techniques are providing novel perspectives on the events that take place in the injured brain, providing a real-time window into post-injury plasticity. These new approaches are likely to accelerate the pace of basic research, and provide a wealth of opportunities to translate basic principles into therapeutic methodologies.

Indexed as

axonal sproutingmotor cortexmotor learningrecoverystroketraumatic brain injury

Identifiers

PMID24399951
PMCPMC3870954
OpenAlexW2124118965

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.