ArticleInternational journal of nanomedicine2014
3D conductive nanocomposite scaffold for bone tissue engineering.
Article in International journal of nanomedicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 186 citations in OpenAlex.
- PEDOT:PSS in peripheral nerve injury repair: electrical stimulation, neural interfaces, and neural regenerative mechanisms.Materials today. Bio · 2026Review
- PEDOT:PSS-A Key Material for Bioelectronics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Electric field stimulation-responsive hydrogels for bone regeneration: from mechanisms to applications.Bone research · 2026Review
- PEDOTs in Bone Tissue Engineering Composites: Fabrication Strategies and Translational Hurdles.Research (Washington, D.C.) · 2026Review
- Thermally-Induced Self-Agglomeration: Method and First Approaches to the Structural, Mechanical and Biological Characterization of Nanofiber Scaffolds.Current topics in medicinal chemistry · 2025Review
- Electrically Active Biomaterials for Stimulation and Regeneration in Tissue Engineering.Journal of biomedical materials research. Part A · 2025Review
- Design and Characterization of Biomimetic Hybrid Construct Based on Hyaluronic Acid and Alginate Bioink for Regeneration of Articular Cartilage.Pharmaceutics · 2024Article
- Advances and Functional Integration of Hydrogel Composites as Drug Delivery Systems in Contemporary Dentistry.Gels (Basel, Switzerland) · 2024Review
- Advances in electroactive biomaterials: Through the lens of electrical stimulation promoting bone regeneration strategy.Journal of orthopaedic translation · 2024Review
- Conductive and alignment-optimized porous fiber conduits with electrical stimulation for peripheral nerve regeneration.Materials today. Bio · 2024Article
- Chitosan/Hyaluronan and Alginate-Nanohydroxyapatite Biphasic Scaffold as a Promising Matrix for Osteoarthritis Disorders.Advanced pharmaceutical bulletin · 2024Article
- A Review on Electroactive Polymer-Metal Composites: Development and Applications for Tissue Regeneration.Journal of functional biomaterials · 2023Review
- Mussel-inspired polydopamine decorated silane modified-electroconductive gelatin-PEDOT:PSS scaffolds for bone regeneration.RSC advances · 2023Article
- Applications of Hydrogels in Drug Delivery for Oral and Maxillofacial Diseases.Gels (Basel, Switzerland) · 2023Review
- Electrically conductive carbon-based (bio)-nanomaterials for cardiac tissue engineering.Bioengineering & translational medicine · 2023Review
- Controlling scaffold conductivity and pore size to direct myogenic cell alignment and differentiation.Journal of biomedical materials research. Part A · 2022Article
- Electroceuticals for peripheral nerve regeneration.Biofabrication · 2022Review
- Advances in Cell-Conductive Polymer Biointerfaces and Role of the Plasma Membrane.Chemical reviews · 2022Article
- Conductive Scaffolds for Bone Tissue Engineering: Current State and Future Outlook.Journal of functional biomaterials · 2021Review
- Conductive Bioimprint Using Soft Lithography Technique Based on PEDOT:PSS for Biosensing.Bioengineering (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone healing can be significantly expedited by applying electrical stimuli in the injured region. Therefore, a three-dimensional (3D) ceramic conductive tissue engineering scaffold for large bone defects that can locally deliver the electrical stimuli is highly desired. In the present study, 3D conductive scaffolds were prepared by employing a biocompatible conductive polymer, ie, poly(3,4-ethylenedioxythiophene) poly(4-styrene sulfonate) (PEDOT:PSS), in the optimized nanocomposite of gelatin and bioactive glass. For in vitro analysis, adult human mesenchymal stem cells were seeded in the scaffolds. Material characterizations using hydrogen-1 nuclear magnetic resonance, in vitro degradation, as well as thermal and mechanical analysis showed that incorporation of PEDOT:PSS increased the physiochemical stability of the composite, resulting in improved mechanical properties and biodegradation resistance. The outcomes indicate that PEDOT:PSS and polypeptide chains have close interaction, most likely by forming salt bridges between arginine side chains and sulfonate groups. The morphology of the scaffolds and cultured human mesenchymal stem cells were observed and analyzed via scanning electron microscope, micro-computed tomography, and confocal fluorescent microscope. Increasing the concentration of the conductive polymer in the scaffold enhanced the cell viability, indicating the improved microstructure of the scaffolds or boosted electrical signaling among cells. These results show that these conductive scaffolds are not only structurally more favorable for bone tissue engineering, but also can be a step forward in combining the tissue engineering techniques with the method of enhancing the bone healing by electrical stimuli.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.