ArticleHuman psychopharmacology2014
Cortisol levels decrease after acute tobacco abstinence in regular smokers.
Article in Human psychopharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 73 citations in OpenAlex.
- Smoking Status and Survival in Patients With Early-Stage Primary Cutaneous Melanoma.JAMA network open · 2024Trial
- The Effect of Music Therapy in Reducing Dental Anxiety and Lowering Physiological Stressors.Acta bio-medica : Atenei Parmensis · 2022Trial
- Differences in mood and cortisol by menstrual phase during acute smoking abstinence: A within-subject comparison.Experimental and clinical psychopharmacology · 2017Trial
- Nicotine withdrawal alters neural responses to psychosocial stress.Psychopharmacology · 2016Trial
- Effects of Lifestyle, Diet, and Body Composition on Free Testosterone and Cortisol Levels in Young Men.Nutrients · 2025Article
- The influence of stress and social defeat on neurobiological reinforcement mechanisms across reward to withdrawal in nicotine addiction.Psychopharmacology · 2025Review
- Effects of electronic smoking on daytime plasma cortisol levels and the possible ameliorating role of physical activity: a cross-sectional study.Journal of Yeungnam medical science · 2025Article
- Targeting GLP-1 receptors to reduce nicotine use disorder: Preclinical and clinical evidence.Physiology & behavior · 2024Review
- Tobacco cessation in patients with multiple chronic conditions: nutritional strategies as an additional tool in treatment.Trends in psychiatry and psychotherapy · 2024Article
- Diurnal variability of cortisol in the Pennsylvania adult smoking study: Exploration of association with nicotine intake.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2023Article
- Pronounced Diurnal Pattern of Salivary C-Reactive Protein (CRP) With Modest Associations to Circulating CRP Levels.Frontiers in immunology · 2020Article
- Racial/Ethnic Differences in Physiological Stress and Relapse among Treatment Seeking Tobacco Smokers.International journal of environmental research and public health · 2019Article
- Music therapy-induced changes in salivary cortisol level are predictive of cardiovascular mortality in patients under maintenance hemodialysis.Therapeutics and clinical risk management · 2017Article
- Salivary melatonin and cortisol and occupational injuries among Italian hospital workers.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2016Article
- Targeting the Brain Stress Systems for the Treatment of Tobacco/Nicotine Dependence: Translating Preclinical and Clinical Findings.Current addiction reports · 2016Article
- Relationship between salivary stress biomarker levels and cigarette smoking in healthy young adults: an exploratory analysis.Tobacco induced diseases · 2016Article
- Longitudinal and Immediate Effect of Kundalini Yoga on Salivary Levels of Cortisol and Activity of Alpha-Amylase and Its Effect on Perceived Stress.International journal of yogaArticle
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveThe aim of this study was to examine the effect of acute tobacco abstinence on cortisol levels in regular smokers, and whether abstinence-induced changes in cortisol levels are correlated with various signs and symptoms of the tobacco withdrawal syndrome.
methodsSmokers (N = 77, ≥15 cigarettes/day) attended two counterbalanced sessions (avg = 1 h), one following 12-20 h of abstinence and the other following ad lib smoking. At both sessions, salivary cortisol levels were measured at three time points. Additionally, a battery of self-report questionnaires, physiological assessments, and cognitive performance tasks were administered to measure signs and symptoms of tobacco withdrawal.
resultsSalivary cortisol levels were significantly lower during the abstinent session versus the non-abstinent session. No significant associations were found between abstinence-induced changes in cortisol and other tobacco withdrawal measures, although there was suggestive evidence that abstinence-induced changes in cortisol levels and hunger were inversely associated to a modest degree.
conclusionAcute tobacco abstinence was associated with decreased cortisol levels. Cortisol dampening during acute tobacco abstinence may reflect nicotine-mediated modulation of hypothalamic-pituitary-adrenal axis activity, which may be relevant to the maintenance of tobacco dependence. Tobacco-withdrawal cortisol changes do not appear to be a cause or consequence of many manifestations of acute tobacco withdrawal with the possible exception of hunger.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.