ArticleeLife2014
Mouse rods signal through gap junctions with cones.
Article in eLife, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
38 citing papers in PubMed.
- Fast ERG 15 Hz flicker protocol for assessing functional changes in the rod system.Documenta ophthalmologica. Advances in ophthalmology · 2026Article
- Light drives the developmental progression of outer retinal function.The Journal of general physiology · 2023Article
- Optical coherence tomography in healthy human subjects in the setting of prolonged dark adaptation.Scientific reports · 2023Article
- Multiple Bioenergy-Linked OCT Biomarkers Suggest Greater-Than-Normal Rod Mitochondria Activity Early in Experimental Alzheimer's Disease.Investigative ophthalmology & visual science · 2023Article
- When microscopy and electrophysiology meet connectomics-Steve Massey's contribution to unraveling the structure and function of the rod/cone gap junction.Frontiers in ophthalmology · 2023Review
- Transducin-Deficient Rod Photoreceptors Evaluated With Optical Coherence Tomography and Oxygen Consumption Rate Energy Biomarkers.Investigative ophthalmology & visual science · 2022Article
- Increased H3K27 trimethylation contributes to cone survival in a mouse model of cone dystrophy.Cellular and molecular life sciences : CMLS · 2022Article
- Divergent outer retinal circuits drive image and non-image visual behaviors.Cell reports · 2022Article
- Analysis of rod/cone gap junctions from the reconstruction of mouse photoreceptor terminals.eLife · 2022Article
- Visual pigment-deficient cones survive and mediate visual signaling despite the lack of outer segments.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- OCT imaging of rod mitochondrial respirationExperimental biology and medicine (Maywood, N.J.) · 2021Review
- Interphotoreceptor coupling: an evolutionary perspective.Pflugers Archiv : European journal of physiology · 2021Review
- Development and maintenance of vision's first synapse.Developmental biology · 2021Review
- Correcting QUEST Magnetic Resonance Imaging-Sensitive Free Radical Production in the Outer Retina In Vivo Does Not Correct Reduced Visual Performance in 24-Month-Old C57BL/6J Mice.Investigative ophthalmology & visual science · 2021Article
- Linear and nonlinear chromatic integration in the mouse retina.Nature communications · 2021Article
- LKB1 and AMPK instruct cone nuclear position to modify visual function.Cell reports · 2021Article
- Function of cone and cone-related pathways in CaScientific reports · 2021Article
- A hybrid stochastic/deterministic model of single photon response and light adaptation in mouse rods.Computational and structural biotechnology journal · 2021Article
- Ex vivo electroretinograms made easy: performing ERGs using 3D printed components.The Journal of physiology · 2020Article
- Effects of Cone Connexin-36 Disruption on Light Adaptation and Circadian Regulation of the Photopic ERG.Investigative ophthalmology & visual science · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rod and cone photoreceptors are coupled by gap junctions (GJs), relatively large channels able to mediate both electrical and molecular communication. Despite their critical location in our visual system and evidence that they are dynamically gated for dark/light adaptation, the full impact that rod-cone GJs can have on cone function is not known. We recorded the photovoltage of mouse cones and found that the initial level of rod input increased spontaneously after obtaining intracellular access. This process allowed us to explore the underlying coupling capacity to rods, revealing that fully coupled cones acquire a striking rod-like phenotype. Calcium, a candidate mediator of the coupling process, does not appear to be involved on the cone side of the junctional channels. Our findings show that the anatomical substrate is adequate for rod-cone coupling to play an important role in vision and, possibly, in biochemical signaling among photoreceptors. DOI: http://dx.doi.org/10.7554/eLife.01386.001.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.