ArticleHuman molecular genetics2014
Seasonal changes in gene expression represent cell-type composition in whole blood.
Article in Human molecular genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Article
- Genetically regulated eRNA expression predicts chromatin contact frequency and reveals genetic mechanisms at GWAS loci.Nature communications · 2025Article
- Involvement of the secosteroid vitamin D in autoimmune rheumatic diseases and COVID-19.Nature reviews. Rheumatology · 2023Review
- A guide to systems-level immunomics.Nature immunology · 2022Review
- Impacts of seasonality on gene expression in the Chinese horseshoe bat.Ecology and evolution · 2022Article
- Variability of multi-omics profiles in a population-based child cohort.BMC medicine · 2021Article
- Cytokine levels in children and adults with wheezing and asthma show specific patterns of variability over time.Clinical and experimental immunology · 2021Article
- Seasonally variant gene expression in full-term human placenta.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- The Human Blood Transcriptome in a Large Population Cohort and Its Relation to Aging and Health.Frontiers in big data · 2020Article
- Genetic regulation of gene expression and splicing during a 10-year period of human aging.Genome biology · 2019Article
- Spring peaks and autumn troughs identified in peripheral inflammatory markers during the peripartum period.Scientific reports · 2019Article
- Blood plasma metabolic profiling of pregnant women with antenatal depressive symptoms.Translational psychiatry · 2019Article
- Article
- Systems Immunology: Learning the Rules of the Immune System.Annual review of immunology · 2018Review
- Modeling Seasonal and Spatiotemporal Variation: The Example of Respiratory Prescribing.American journal of epidemiology · 2017Article
- Human immune system variation.Nature reviews. Immunology · 2017Review
- Peripheral blood gene expression profiles linked to monoamine metabolite levels in cerebrospinal fluid.Translational psychiatry · 2016Article
- Article
- RNA-Seq analysis of seasonal and individual variation in blood transcriptomes of healthy managed bottlenose dolphins.BMC genomics · 2016Article
- Common Aging Signature in the Peripheral Blood of Vascular Dementia and Alzheimer's Disease.Molecular neurobiology · 2016Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
Seasonal patterns in behavior and biological parameters are widespread. Here, we examined seasonal changes in whole blood gene expression profiles of 233 healthy subjects. Using weighted gene co-expression network analysis, we identified three co-expression modules showing circannual patterns. Enrichment analysis suggested that this signal stems primarily from red blood cells and blood platelets. Indeed, a large clinical database with 51 142 observations of blood cell counts over 3 years confirmed a corresponding seasonal pattern of counts of red blood cells, reticulocytes and platelets. We found no direct evidence that these changes are linked to genes known to be key players in regulating immune function or circadian rhythm. It is likely, however, that these seasonal changes in cell counts and gene expression profiles in whole blood represent biological and clinical relevant phenomena. Moreover, our findings highlight possible confounding factors relevant to the study of gene expression profiles in subjects collected at geographical locations with disparaging seasonality patterns.
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