ArticleJournal of experimental botany2014
A trade off between mlo resistance to powdery mildew and increased susceptibility of barley to a newly important disease, Ramularia leaf spot.
Article in Journal of experimental botany, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed.
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- CRISPR-mediated genome editing of wheat for enhancing disease resistance.Frontiers in genome editing · 2025Review
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- Identification of Quantitative Trait Loci Associated with Powdery Mildew Resistance in Spring Barley under Conditions of Southeastern Kazakhstan.Plants (Basel, Switzerland) · 2023Article
- A unique resistance mechanism is associated with RBgh2 barley powdery mildew adult plant resistance.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- Ambivalent response in pathogen defense: A double-edged sword?Plant communications · 2022Review
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- Communication is key: extracellular vesicles as mediators of infection and defence during host-microbe interactions in animals and plants.FEMS microbiology reviews · 2022Review
- Pyramiding of scald resistance genes in four spring barley MAGIC populations.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2021Article
- Mutations in a barley cytochrome P450 gene enhances pathogen induced programmed cell death and cutin layer instability.PLoS genetics · 2021Article
- Ecological and evolutionary approaches to improving crop variety mixtures.Nature ecology & evolution · 2021Review
- Genome editing for resistance against plant pests and pathogens.Transgenic research · 2021Review
- Understanding and Exploiting Post-Translational Modifications for Plant Disease Resistance.Biomolecules · 2021Review
- Fungicide Resistance Evolving inMicroorganisms · 2021Article
- Discovery and Characterization of a Novel TomatoGenes · 2021Article
- CmMLO17 and its partner CmKIC potentially support Alternaria alternata growth in Chrysanthemum morifolium.Horticulture research · 2021Article
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8 authors.
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Abstract
Ramularia leaf spot (RLS), caused by the fungus Ramularia collo-cygni, is a serious, recently emerged disease of barley in Europe and other temperate regions. This study investigated the trade off between strong resistance to powdery mildew conferred by mlo mutant alleles and increased susceptibility to RLS. In field trials and seedling tests, the presence of mlo alleles increased severity of RLS. Genetic analysis of a doubled-haploid population identified one quantitative trait locus for susceptibility to RLS, colocalizing with the mlo-11 allele for mildew resistance. The effect of mlo-11 on RLS severity was environmentally sensitive. Analysis of near-isogenic lines of different mlo mutations in various genetic backgrounds confirmed that mlo alleles increased RLS severity in seedlings and adult plants. For mlo resistance to mildew to be fully effective, the genes ROR1 and ROR2 are required. RLS symptoms were significantly reduced on mlo-5 ror double mutants but fungal DNA levels remained as high as in mlo-5 single mutants, implying that ror alleles modify the transition of the fungus from endophytism to necrotrophy. These results indicate that the widespread use of mlo resistance to control mildew may have inadvertently stimulated the emergence of RLS as a major disease of barley.
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