ArticleEuropean journal of applied physiology2014
Repeated core temperature elevation induces conduit artery adaptation in humans.
Article in European journal of applied physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 51 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Local Heat Stress Via Leg Bath on Artery Function
The Effects of 8 Weeks of Lower Limb Heat Therapy, Moderate-intensity Cycling Exercise, or Both on Vascular Function in Young, Healthy Males and Females
Vascular and Neural Mechanisms of Chronic Leg Heating in Pregnant Women With Obesity
Who cites it
51 citing papers in PubMed, 87 citations in OpenAlex.
- Post-exercise hot water immersion enhances haemodynamic and vascular benefits of exercise without further improving cardiorespiratory fitness, glucose, lipids or inflammation.The Journal of physiology · 2025Trial
- Impact of resistance and endurance exercise training on femoral artery function: sex differences in humans.The Journal of physiology · 2025Trial
- The effect of a 4-week, remotely administered, post-exercise passive leg heating intervention on determinants of endurance performance.European journal of applied physiology · 2024Trial
- Acute hot water immersion is protective against impaired vascular function following forearm ischemia-reperfusion in young healthy humans.American journal of physiology. Regulatory, integrative and comparative physiology · 2016Trial
- Comparison between exercise and hot water immersion on skin microvascular responses in older adults with overweight and obesity.European journal of applied physiology · 2026Article
- Sex differences in macrovascular responsiveness: Acute effects of hot water immersion versus aerobic exercise in overweight older adults.Experimental physiology · 2026Article
- Comparison of exercise training and repeated hot water immersion on vascular function in overweight older adults.Experimental physiology · 2026Article
- Identifying the interaction between skin temperature, maintained thermal comfort, and conduit artery shear rate through limb passive heating.Physiological reports · 2026Article
- The effect of repeated hot water immersion on microvascular function, glycaemic control and inflammation in White European and South Asian males.Experimental physiology · 2026Article
- Acute measurement of flow-mediated dilation following passive heating in adults: The confounding role of altered shear stress and baseline vasodilation.Physiological reports · 2026Article
- Eight weeks of post-exercise local heating does not improve cognition and plasma brain-derived neurotrophic factor concentrations.Experimental physiology · 2025Article
- Influence of Foot and Legwear Color on Lower-Limb Temperature in Baseball Players Under Heat Stress.Sports (Basel, Switzerland) · 2025Article
- Vascular, inflammatory and perceptual responses to hot water immersion: Impacts of water depth and temperature in young healthy adults.Experimental physiology · 2025Article
- Comparison of thermoregulatory, cardiovascular, and immune responses to different passive heat therapy modalities.American journal of physiology. Regulatory, integrative and comparative physiology · 2025Article
- The acute effects of continuous and intermittent whole-body passive heating on cardiovascular disease risk indicators in healthy and young males and females.European journal of applied physiology · 2025Article
- Muscle temperature increases during a single far infrared sauna session without changes in intestinal temperature.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- Home-based heat therapy lowers blood pressure and improves endothelial function in older adults.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- The effect of acute hot water immersion on cutaneous peripheral microvascular responses in males of White-European, Black-African and South-Asian descent.Temperature (Austin, Tex.) · 2025Article
- Cardiovascular and mood responses to an acute bout of cold water immersion.Journal of thermal biology · 2023Article
- The effect of age and mitigation strategies during hot water immersion on orthostatic intolerance and thermal stress.Experimental physiology · 2023Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeShear stress is a known stimulus to vascular adaptation in humans. However, it is not known whether thermoregulatory reflex increases in blood flow and shear can induce conduit artery adaptation.
methodsTen healthy young volunteers therefore underwent 8 weeks of 3 × weekly bouts of 30 min lower limb heating (40 °C) during which the upper body was not directly heated. Throughout each leg heating session, a pneumatic cuff was placed on one forearm and inflated to unilaterally restrict reflex-mediated blood flow responses.
resultsEach bout of leg heating significantly increased brachial artery shear rate in the uncuffed arm (96 ± 97 vs 401 ± 96 l/s, P < 0.01), whereas no change was apparent in the cuffed arm (83 ± 69 vs 131 ± 76 l/s, P = 0.67). Repeated episodic exposure to leg heating enhanced brachial artery endothelial function (measured by flow-mediated dilation) in the uncuffed arm from week 0 (5.2 ± 1.9 %) to week 4 (7.7 ± 2.6 %, P < 0.05), before returning to baseline levels by week 8. No adaptation was evident in the cuffed arm.
conclusionsWe conclude that repeated increases in core temperature, induced via lower limb heating, resulted in upper limb conduit artery vascular adaptation which was dependent upon increases in shear stress. To our knowledge this is the first study to establish a beneficial systemic impact of thermoregulatory reflexes on conduit artery function in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.