Evidence map›Paper›PMID 24398512›Full record

ArticleBritish journal of cancer2014

Oral contraceptive and reproductive risk factors for ovarian cancer within sisters in the breast cancer family registry.

J S Ferris, M B Daly, S S Buys, J M Genkinger, Y Liao, M B Terry

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of cancer, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

J S FerrisDepartment of Epidemiology, Columbia University, Mailman School of Public Health, New York, NY 10032, USA.
M B DalyFox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111-2497, USA.
S S BuysHuntsman Cancer Institute, University of Utah Health Sciences Center, Salt Lake City, UT 84112, USA.
J M GenkingerDepartment of Epidemiology, Columbia University, Mailman School of Public Health, New York, NY 10032, USA.
Y LiaoDepartment of Epidemiology, Columbia University, Mailman School of Public Health, New York, NY 10032, USA.
M B Terry1] Department of Epidemiology, Columbia University, Mailman School of Public Health, New York, NY 10032, USA [2] Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10032, USA.

Funding

Breast Cancer Family Registry CohortUM1CA164920 · NCI · CANCER PREVENTION INSTIT OF CALIFORNIA · PI ANDRULIS, IRENE, BUYS, SAUNDRA S · 2012 to 2017
$12.7M
METROPOLITAN NEW YORK REGISTRY OF BREAST CANCER FAMILIESU01CA069398 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI TERRY, MARY BETH · 1995 to 2010
$10.5M
Philadelphia Breast Cancer Family RegistryU01CA069631 · NCI · FOX CHASE CANCER CENTER · PI DALY, MARY BERYL · 1995 to 2010
$7.4M
Utah Breast Cancer Family RegistryU01CA069446 · NCI · UNIVERSITY OF UTAH · PI BUYS, SAUNDRA S · 1995 to 2010
$4.6M
NCI NIH HHS CA-06-503NCI NIH HHS HHSN261200900010CNCI NIH HHS U01 CA069398NCI NIH HHS U01 CA069446NCI NIH HHS U01 CA069631NCI NIH HHS U01 CA69398NCI NIH HHS U01 CA69446NCI NIH HHS U01 CA69631NCI NIH HHS UM1 CA164920
6 · The paper itself

Abstract

backgroundOral contraceptive use has been consistently associated with a reduced risk of ovarian cancer in unrelated, average risk women; however little data exist on whether this benefit extends to higher risk women from cancer families. To examine this, we conducted family-based analyses using the Breast Cancer Family Registry.

methodsWe used generalised estimating equations to obtain the population average effect across all families (n=389 cases, n=5643 controls) and conditional logistic regression to examine within-family differences in a subset with at least two sisters discordant on ovarian cancer status (n=109 cases, n=149 unaffected sister controls).

resultsIn the multivariable generalised estimating equation model there was a reduced risk of ovarian cancer for ever use of oral contraceptives compared with never use (OR=0.58, 95% CI: 0.37, 0.91), and in the conditional logistic model there was a similar inverse association; however, it was not statistically significant (OR=0.52, 95% CI: 0.23, 1.17). We examined this association by BRCA1/2 status and observed a statistically significant reduced risk in the non-carriers only.

conclusionWe observed a decreased risk of ovarian cancer with oral contraceptive use supporting that this association observed in unrelated women extends to related women at higher risk.

Indexed as

BRCA1 ProteinBRCA2 ProteinBreast NeoplasmsContraceptives, OralFemaleHumansMiddle AgedOvarian NeoplasmsRiskRisk AssessmentRisk FactorsSiblingsSurveys and QuestionnairesBRCA1 ProteinBRCA1 protein, humanBRCA2 ProteinBRCA2 protein, humanContraceptives, Oral

Identifiers

PMID24398512
PMCPMC3929882

What OpenQuestion holds

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LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.