ArticleAmerican journal of physiology. Endocrinology and metabolism2014
Leanness and heightened nonresting energy expenditure: role of skeletal muscle activity thermogenesis.
Article in American journal of physiology. Endocrinology and metabolism, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed.
- The associations between resting and total energy expenditure, physical activity, and thyroid hormone levels in adult females.Frontiers in physiology · 2026Article
- Exposure to predator threat engages sympathetic nervous system outflow to skeletal muscle.Autonomic neuroscience : basic & clinical · 2025Article
- Impact of Dietary Intake and Cardiorespiratory Fitness on Glycemic Variability in Adolescents: An Observational Study.Current developments in nutrition · 2025Article
- Article
- Weight loss in adult male Wistar rats by Roux-en-Y gastric bypass is primarily explained by caloric intake reduction and presurgery body weight.American journal of physiology. Regulatory, integrative and comparative physiology · 2024Article
- Divergence in aerobic capacity and energy expenditure influence metabolic tissue mitochondrial protein synthesis rates in aged rats.GeroScience · 2024Article
- Intrinsic cardiorespiratory fitness modulates clinical and molecular response to caloric restriction.Molecular metabolism · 2023Article
- Reduced contextually induced muscle thermogenesis in rats with calorie restriction and lower aerobic fitness but not monogenic obesity.Temperature (Austin, Tex.) · 2023Article
- Altered skeletal muscle sarco-endoplasmic reticulum CaAmerican journal of physiology. Regulatory, integrative and comparative physiology · 2022Article
- Brown to White Fat Transition Overlap With Skeletal Muscle During Development of Larger Mammals: Is it a Coincidence?Journal of the Endocrine Society · 2022Review
- High Cardiorespiratory Fitness Protects against Molecular Impairments of Metabolism, Heart, and Brain with Higher Efficacy in Obesity-Induced Premature Aging.Endocrinology and metabolism (Seoul, Korea) · 2022Article
- Measuring Skeletal Muscle Thermogenesis in Mice and Rats.Journal of visualized experiments : JoVE · 2022Article
- Differential weight loss with intermittent fasting or daily calorie restriction in low- and high-fitness phenotypes.Experimental physiology · 2021Article
- Efficacy of Dietary and Supplementation Interventions for Individuals with Type 2 Diabetes.Nutrients · 2021Review
- The Effect of Dietary Intake and Nutritional Status on Anthropometric Development and Systemic Inflammation: An Observational Study.International journal of environmental research and public health · 2021Observational
- Enhanced weight and fat loss from long-term intermittent fasting in obesity-prone, low-fitness rats.Physiology & behavior · 2021Article
- Aerobic capacity modulates adaptive thermogenesis: Contribution of non-resting energy expenditure.Physiology & behavior · 2020Article
- Skeletal muscle thermogenesis induction by exposure to predator odor.The Journal of experimental biology · 2020Article
- Differential Sympathetic Activation of Adipose Tissues by Brain-Derived Neurotrophic Factor.Biomolecules · 2019Article
- Caffeine enhances activity thermogenesis and energy expenditure in rats.Clinical and experimental pharmacology & physiology · 2019Article
Corrections and comments
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Authors and funding
7 authors.
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Abstract
A high-calorie diet accompanied by low levels of physical activity (PA) accounts for the widespread prevalence of obesity today, and yet some people remain lean even in this obesogenic environment. Here, we investigate the cause for this exception. A key trait that predicts high PA in both humans and laboratory rodents is intrinsic aerobic capacity. Rats artificially selected as high-capacity runners (HCR) are lean and consistently more physically active than their low-capacity runner (LCR) counterparts; this applies to both males and females. Here, we demonstrate that HCR show heightened total energy expenditure (TEE) and hypothesize that this is due to higher nonresting energy expenditure (NREE; includes activity EE). After matching for body weight and lean mass, female HCR consistently had heightened nonresting EE, but not resting EE, compared with female LCR. Because of the dominant role of skeletal muscle in nonresting EE, we examined muscle energy use. We found that lean female HCR had higher muscle heat dissipation during activity, explaining their low economy of activity and high activity EE. This may be due to the amplified skeletal muscle expression levels of proteins involved in EE and reduced expression levels of proteins involved in energy conservation in HCR relative to LCR. This is also associated with an increased sympathetic drive to skeletal muscle in HCR compared with LCR. We find little support for the hypothesis that resting metabolic rate is correlated with maximal aerobic capacity if body size and composition are fully considered; rather, the critical factor appears to be activity thermogenesis.
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