Evidence map›Paper›PMID 24398227›Full record

ArticleVeterinary microbiology2014

Correlation of cell surface marker expression with African swine fever virus infection.

Pamela Lithgow, Haru Takamatsu, Dirk Werling, Linda Dixon, Dave Chapman

Open access · hybridAbstract read
In one paragraph

Article in Veterinary microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 89 citations in OpenAlex.

  1. Article
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  10. Selection for Resilience in Livestock Production Systems.International journal of molecular sciences · 2024
    Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. When ASFV Infection Meets the cGAS-STING Signaling Pathway.Transboundary and emerging diseases · 2024
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Pamela LithgowThe Pirbright Institute, Ash Road, Pirbright GU24 0NF, United Kingdom.
Haru TakamatsuThe Pirbright Institute, Ash Road, Pirbright GU24 0NF, United Kingdom.
Dirk WerlingRoyal Veterinary College, Hawkshead Lane, Hertfordshire AL9 7TA, United Kingdom.
Linda DixonThe Pirbright Institute, Ash Road, Pirbright GU24 0NF, United Kingdom.
Dave ChapmanThe Pirbright Institute, Ash Road, Pirbright GU24 0NF, United Kingdom. Electronic address: dave.chapman@pirbright.ac.uk.
The Pirbright Institute · GBRoyal Veterinary College · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The expression of surface markers on African swine fever virus (ASFV) infected cells was evaluated to assess their involvement in infection. Previous findings indicated CD163 expression was correlated with ASFV susceptibility. However, in this study the expression of porcine CD163 on cell lines did not increase the infection rate of these cells indicating other factors are likely to be important in determining susceptibility to infection. On adherent porcine bone marrow (pBM) cells the expression of CD45 was strongly correlated with infection. CD163 and CD203a expression correlated at intermediate levels with infection, indicating cells expressing these markers could become infected but were not preferentially infected by the virus. Most of the cells expressing MHCII were infected, indicating that they may be preferentially infected although expression of MHCII was not essential for infection and a large percentage of the infected cells were MHCII negative. CD16 showed a marked decrease in expression following infection and significantly lower levels of infected cells were shown to express CD16. Altogether these results suggest CD163 may be involved in ASFV infection but it may not be essential; the results also highlight the importance of other cell markers which requiring further investigation.

Indexed as

African Swine FeverAfrican Swine Fever VirusAnimalsAntigens, CDAntigens, Differentiation, MyelomonocyticBiomarkersBone Marrow CellsCD163 AntigenCell LineChlorocebus aethiopsFlow CytometryGenes, MHC Class IILeukocyte Common AntigensMacrophagesMembrane ProteinsReceptors, Cell SurfaceAntigens, CDAntigens, Differentiation, MyelomonocyticBiomarkersCD163 AntigenLeukocyte Common AntigensMembrane ProteinsReceptors, Cell SurfaceAfrican swine fever virusCD163CD203aCD45MHCIISurface markers

Identifiers

PMID24398227
PMCPMC3969584
OpenAlexW2055579914

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.