Evidence map›Paper›PMID 24398106›Full record

ReviewToxicology and applied pharmacology2014

Oxidative stress-induced autophagy: role in pulmonary toxicity.

Rama Malaviya, Jeffrey D Laskin, Debra L Laskin

Abstract readReview
In one paragraph

Review in Toxicology and applied pharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. AlfalfaInternational journal of molecular sciences · 2023
    Article
  3. Oxidative medicine and cellular longevity · 2023
    Article
  4. Ehretiquinone fromOxidative medicine and cellular longevity · 2021
    Article
  5. Review
  6. Article
  7. Review
  8. Alcohol and lung injury and immunity.Alcohol (Fayetteville, N.Y.) · 2016
    Review
  9. Article
  10. Role of Nrf2 and Autophagy in Acute Lung Injury.Current pharmacology reports · 2016
    Article
  11. Article
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Rama MalaviyaDepartment of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854, USA.
Jeffrey D LaskinDepartment of Environmental and Occupational Medicine, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ 08854, USA.
Debra L LaskinDepartment of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854, USA. Electronic address: laskin@eohsi.rutgers.edu.

Funding

UMDNJ/Rutgers University CounterACT Research Center of ExcellenceU54AR055073 · NIAMS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI LASKIN, JEFFREY D · 2006 to 2024
$71.4M
Translational Research Support CoreP30ES005022 · NIEHS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI PANOS G. GEORGOPOULOS · 1988 to 2026
$47.4M
ACTIVATED MACROPHAGES AND OZONE TOXICITYR01ES004738 · NIEHS · RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK · PI Debra L Laskin · 1989 to 2026
$9.0M
Macrophages and Inflammatory Mediators in Silica-Induced CarcinogenesisR01CA132624 · NCI · RUTGERS, THE STATE UNIV OF N.J. · PI LASKIN, DEBRA L · 2008 to 2012
$1.5M
Role of Nitric Oxide in Radiation-Induced Lung InjuryK01HL096426 · NHLBI · RUTGERS, THE STATE UNIV OF N.J. · PI MALAVIYA, RAMA · 2009 to 2013
$706k
NCI NIH HHS R01 CA132624NCI NIH HHS R01CA132624NHLBI NIH HHS K01 HL096426NHLBI NIH HHS K08HL096426NIAMS NIH HHS U54 AR055073NIAMS NIH HHS U54AR055073NIEHS NIH HHS P30 ES005022NIEHS NIH HHS P30ES005022NIEHS NIH HHS R01 ES004738NIEHS NIH HHS R01ES004738
6 · The paper itself

Abstract

Autophagy is an evolutionarily conserved catabolic process important in regulating the turnover of essential proteins and in elimination of damaged organelles and protein aggregates. Autophagy is observed in the lung in response to oxidative stress generated as a consequence of exposure to environmental toxicants. Whether autophagy plays role in promoting cell survival or cytotoxicity is unclear. In this article recent findings on oxidative stress-induced autophagy in the lung are reviewed; potential mechanisms initiating autophagy are also discussed. A better understanding of autophagy and its role in pulmonary toxicity may lead to the development of new strategies to treat lung injury associated with oxidative stress.

Indexed as

Air PollutantsAnimalsAutophagyHumansLungLung InjuryOxidative StressReactive Oxygen SpeciesUp-RegulationAir PollutantsReactive Oxygen SpeciesAutophagyCytotoxicityLung injuryOxidative stressp62Pulmonary toxicants

Identifiers

PMID24398106
PMCPMC4455034

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.