ArticleMolecular pain2014
Loss of long-term depression in the insular cortex after tail amputation in adult mice.
Article in Molecular pain, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 40 citations in OpenAlex.
- GluK1-containing kainate receptor-dependent long-term depression in the anterior cingulate cortex modulates chronic pain.Journal of translational medicine · 2026Article
- Metabotropic Glutamate Receptor-Dependent Synaptic Plasticity in Age-Related Neurodegenerative Disorders.Neural plasticity · 2026Review
- Cortical Potentiation in Chronic Neuropathic Pain and the Future Treatment.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Cortical Tagged Synaptic Long-Term Depression in the Anterior Cingulate Cortex of Adult Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Enhanced long-term potentiation in the anterior cingulate cortex of tree shrew.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- Alleviation of migraine related pain and anxiety by inhibiting calcium-stimulating AC1-dependent CGRP in the insula of adult rats.The journal of headache and pain · 2024Article
- Long-Lasting, Pathway-Specific Impairment of a Novel Form of Spike-Timing-Dependent Long-Term Depression by Neuropathic Pain in the Anterior Cingulate Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Aberrant functional connectivity in insular subregions in somatic depression: a resting-state fMRI study.BMC psychiatry · 2022Article
- Cortical potentiation induced by calcitonin gene-related peptide (CGRP) in the insular cortex of adult mice.Molecular brain · 2020Article
- Loss of Synaptic Tagging in the Anterior Cingulate Cortex after Tail Amputation in Adult Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Ethanol Modulates Glutamatergic Transmission and NMDAR-Mediated Synaptic Plasticity in the Agranular Insular Cortex.Frontiers in pharmacology · 2018Article
- Characterization of short- and long-term mechanical sensitisation following surgical tail amputation in pigs.Scientific reports · 2017Article
- Neonatal Maternal Deprivation Enhances Presynaptic P2X7 Receptor Transmission in Insular Cortex in an Adult Rat Model of Visceral Hypersensitivity.CNS neuroscience & therapeutics · 2017Article
- Metabotropic glutamate receptor dependent long-term depression in the cortex.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2016Review
- Acid-sensing ion channel 1a contributes to hippocampal LTP inducibility through multiple mechanisms.Scientific reports · 2016Article
- Metabotropic Glutamate Receptor Dependent Cortical Plasticity in Chronic Pain.Current neuropharmacology · 2016Review
- Minocycline does not affect long-term potentiation in the anterior cingulate cortex of normal adult mice.Molecular pain · 2015Article
- Adenylyl cyclase subtype 1 is essential for late-phase long term potentiation and spatial propagation of synaptic responses in the anterior cingulate cortex of adult mice.Molecular pain · 2014Article
- GluA1 phosphorylation contributes to postsynaptic amplification of neuropathic pain in the insular cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- No requirement of TRPV1 in long-term potentiation or long-term depression in the anterior cingulate cortex.Molecular brain · 2014Article
Corrections and comments
- Erratum issued
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
The insular cortex (IC) is an important forebrain structure involved in pain perception and taste memory formation. Using a 64-channel multi-electrode array system, we recently identified and characterized two major forms of synaptic plasticity in the adult mouse IC: long-term potentiation (LTP) and long-term depression (LTD). In this study, we investigate injury-related metaplastic changes in insular synaptic plasticity after distal tail amputation. We found that tail amputation in adult mice produced a selective loss of low frequency stimulation-induced LTD in the IC, without affecting (RS)-3,5-dihydroxyphenylglycine (DHPG)-evoked LTD. The impaired insular LTD could be pharmacologically rescued by priming the IC slices with a lower dose of DHPG application, a form of metaplasticity which involves activation of protein kinase C but not protein kinase A or calcium/calmodulin-dependent protein kinase II. These findings provide important insights into the synaptic mechanisms of cortical changes after peripheral amputation and suggest that restoration of insular LTD may represent a novel therapeutic strategy against the synaptic dysfunctions underlying the pathophysiology of phantom pain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.