ArticleJournal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons2014
Stage 0 osteonecrosis of the jaw in a patient on denosumab.
Article in Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Early imaging signs of the use of antiresorptive medication and MRONJ: a systematic review.Clinical oral investigations · 2020Pooled it
- Denosumab for Effective Tumor Size Reduction in Patients With Giant Cell Tumors of the Bone: A Systematic Review and Meta-Analysis.Cancer control : journal of the Moffitt Cancer CenterPooled it
- Decoding Epigenetic Switches: How Histone Acetylation/Deacetylation Regulates Mononuclear/Macrophage Fate in Bone Disorders.International journal of biological sciences · 2026Review
- Oral surgery considerations in patients at high-risk of complications related to drug intake: A systematic review.The Saudi dental journal · 2024Review
- Three-dimensional clinical assessment for MRONJ risk in oncologic patients following tooth extractions.Dento maxillo facial radiology · 2023Article
- Osteonecrosis of the Jaw.Dentistry journal · 2023Review
- Inhibition of HMGB1/RAGE Signaling Reduces the Incidence of Medication-Related Osteonecrosis of the Jaw (MRONJ) in Mice.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022Article
- Radiographic predictors for MRONJ in oncologic patients undergoing tooth extraction.Scientific reports · 2022Article
- Nonexposed antiresorptive agent-related osteomyelitis of the jaw: a single-center cohort study.Journal of bone and mineral metabolism · 2022Article
- Do various imaging modalities provide potential early detection and diagnosis of medication-related osteonecrosis of the jaw? A review.Dento maxillo facial radiology · 2021Review
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- Does CBCT alter the diagnostic thinking efficacy, management and prognosis of patients with suspected Stage 0 medication-related osteonecrosis of the jaws?Dento maxillo facial radiology · 2018Article
- Osteonecrosis of the Jaw in the Absence of Antiresorptive or Antiangiogenic Exposure: A Series of 6 Cases.Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons · 2017Article
- Osteonecrosis of the jaw induced by receptor activator of nuclear factor-kappa B ligand (Denosumab) - Review.Medicina oral, patologia oral y cirugia bucal · 2016Review
- Gnathodiaphyseal dysplasia: report of a family with a novel mutation of the ANO5 gene.Oral surgery, oral medicine, oral pathology and oral radiology · 2016Article
- Denosumab-associated osteonecrosis of the jaw affects osteoclast formation and differentiation: Pathological features of two cases.Molecular and clinical oncology · 2016Article
- A Model for Osteonecrosis of the Jaw with Zoledronate Treatment following Repeated Major Trauma.PloS one · 2015Article
- Bone metastases treatment by sm-153 oxabifore in combination with monoclonal antibody denosumab (xgeva).World journal of nuclear medicine · 2014Article
- Medication-related osteonecrosis of the jaw in Northern Thailand: A one-year cohort study of risk factors, incidence, and healing outcomes.Journal of oral biology and craniofacial researchArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Osteonecrosis of the jaws (ONJ) is a complex disease involving multiple tissue and cell-type responses to wound healing or infection. AAOMS defines bisphosphonate related ONJ (BRONJ) as exposed, necrotic bone in the maxillofacial region that has persisted for more than 8 weeks in a patient with current or previous antiresorptive treatment, without a history of radiation therapy to the jaws. Since the first reported ONJ cases in 2003 and 2004, there has been little advancement in understanding the etiology and pathophysiology of ONJ. Many hypotheses have been proposed, including bisphosphonate (BP) toxicity to oral epithelium, altered wound healing after tooth extraction, high turnover of the mandible and maxilla, oral biofilm formation, infection and inflammation, and suppression of angiogenesis and bone turnover. The current classification system of ONJ involves stages 0 to 3 and is based on patient clinical presentation. This report describes a case of stage 0 ONJ in a patient on denosumab and indicates the full-spectrum similarities between BP- and denosumab-associated ONJ clinically, radiographically, and histologically.
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