ArticleJournal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie2014
A joint analysis to identify loci underlying variation in nematode resistance in three European sheep populations.
Article in Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Genomic Regions Associated with Resistance to Gastrointestinal Nematode Parasites in Sheep-A Review.Genes · 2024Review
- Association analysis and functional annotation of imputed sequence data within genomic regions influencing resistance to gastro-intestinal parasites detected by an LDLA approach in a nucleus flock of Sarda dairy sheep.Genetics, selection, evolution : GSE · 2022Article
- Single Nucleotide Polymorphism Effects on Lamb Fecal Egg Count Estimated Breeding Values in Progeny-Tested Katahdin Sires.Frontiers in genetics · 2022Article
- Genetic × environment variation in sheep lines bred for divergent resistance to strongyle infection.Evolutionary applications · 2021Article
- British Sheep Breeds as a Part of World Sheep Gene Pool Landscape: Looking into Genomic Applications.Animals : an open access journal from MDPI · 2021Review
- Mapping genomic regions affecting milk traits in Sarda sheep by using the OvineSNP50 Beadchip and principal components to perform combined linkage and linkage disequilibrium analysis.Genetics, selection, evolution : GSE · 2019Article
- Detection of genomic regions underlying resistance to gastrointestinal parasites in Australian sheep.Genetics, selection, evolution : GSE · 2019Article
- Using imputed whole-genome sequence data to improve the accuracy of genomic prediction for parasite resistance in Australian sheep.Genetics, selection, evolution : GSE · 2019Article
- Lupin (Lupinus spp.) seeds exert anthelmintic activity associated with their alkaloid content.Scientific reports · 2019Article
- Novel and known signals of selection for fat deposition in domestic sheep breeds from Africa and Eurasia.PloS one · 2019Article
- Exploring the mechanisms of resistance to Teladorsagia circumcincta infection in sheep through transcriptome analysis of abomasal mucosa and abomasal lymph nodes.Veterinary research · 2018Article
- Genomic regions underlying susceptibility to bovine tuberculosis in Holstein-Friesian cattle.BMC genetics · 2017Article
- Unveiling genomic regions that underlie differences between Afec-Assaf sheep and its parental Awassi breed.Genetics, selection, evolution : GSE · 2017Article
- Breeding for resistance to gastrointestinal nematodes - the potential in low-input/output small ruminant production systems.Veterinary parasitology · 2016Review
- Species discrimination in the subfamily Ostertagiinae of Northern China: assessment of DNA barcode in a taxonomically challenging group.Parasitology research · 2016Article
- Detection and replication of QTL underlying resistance to gastrointestinal nematodes in adult sheep using the ovine 50K SNP array.Genetics, selection, evolution : GSE · 2016Article
- Genomic prediction and genome-wide association study for dagginess and host internal parasite resistance in New Zealand sheep.BMC genomics · 2015Article
- Genome-wide association study of footrot in Texel sheep.Genetics, selection, evolution : GSE · 2015Article
- Fecal egg counts for gastrointestinal nematodes are associated with a polymorphism in the MHC-DRB1 gene in the Iranian Ghezel sheep breed.Frontiers in genetics · 2015Article
- Functional investigation of a QTL affecting resistance to Haemonchus contortus in sheep.Veterinary research · 2014Article
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Authors and funding
8 authors.
Funding
Abstract
Gastrointestinal nematode infections are one of the main health/economic issues in sheep industries, worldwide. Indicator traits for resistance such as faecal egg count (FEC) are commonly used in genomic studies; however, published results are inconsistent among breeds. Meta (or joint)-analysis is a tool for aggregating information from multiple independent studies. The aim of this study was to identify loci underlying variation in FEC, as an indicator of nematode resistance, in a joint analysis using data from three populations (Scottish Blackface, Sarda × Lacaune and Martinik Black-Belly × Romane), genotyped with the ovine 50k SNP chip. The trait analysed was the average animal effect for Strongyles and Nematodirus FEC data. Analyses were performed with regional heritability mapping (RHM), fitting polygenic effects with either the whole genomic relationship matrix or matrices excluding the chromosome being interrogated. Across-population genomic covariances were set to zero. After quality control, 4123 animals and 38 991 SNPs were available for the analysis. RHM identified genome-wide significant regions on OAR4, 12, 14, 19 and 20, with the latter being the most significant. The OAR20 region is close to the major histocompatibility complex, which has often been proposed as a functional candidate for nematode resistance. This region was significant only in the Sarda × Lacaune population. Several other regions, on OAR1, 3, 4, 5, 7, 12, 19, 20 and 24, were significant at the suggestive level.
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