ReviewChronobiology international2014
Bright light therapy for depression: a review of its effects on chronobiology and the autonomic nervous system.
Review in Chronobiology international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07002554 (The LIGHT-60 Trial - Light Intervention for Geriatric Patients Hospitalized for Depression Treatment), which is not on this map. Cited by 40 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The LIGHT-60 Trial - Light Intervention for Geriatric Patients Hospitalized for Depression Treatment
Who cites it
40 citing papers in PubMed, 4 syntheses or guidelines pooled it, 107 citations in OpenAlex.
- Circadian light therapy and light dose for depressed young people: a systematic review and meta-analysis.Frontiers in public health · 2023Pooled it
- Pooled it
- Second-generation antidepressants for treatment of seasonal affective disorder.The Cochrane database of systematic reviews · 2021Pooled it
- Efficacy and safety of bright light therapy for manic and depressive symptoms in patients with bipolar disorder: A systematic review and meta-analysis.Psychiatry and clinical neurosciences · 2020Pooled it
- Impact of repeated morning bright white light exposures on attention in a simulated office environment.Scientific reports · 2023Trial
- Adjunctive Bright Light Therapy for Non-Seasonal Major Depressive Disorder: A Randomized Controlled Trial.International journal of environmental research and public health · 2022Trial
- Moderators of Cognitive Therapy and Bright Light Therapy Effects on Depressive Symptoms in Patients with Breast Cancer.International journal of behavioral medicine · 2019Trial
- Article
- Chronotherapy to reinforce circadian rhythms improves poststroke outcomes and glymphatic function in mice.The Journal of clinical investigation · 2026Article
- Outdoor activities and social support on anxiety in Chinese older adults: a cross-sectional study.Frontiers in public health · 2026Article
- Mapping the Connection Between Circadian Rhythms, Metabolism, and Neurodegeneration: Exploring Therapeutic Strategies.Current Alzheimer research · 2025Review
- Vitamin D and cancer-related fatigue in elderly patients: mechanisms and therapeutic insights-a narrative review.Frontiers in nutrition · 2025Review
- Light Therapy for Older People with Depressive Symptoms: Systematic Review and Meta-Analysis.Journal of clinical medicine · 2024Review
- The Role of Circadian Rhythms and Sleep in Anorexia Nervosa.JAMA network open · 2024Article
- Bright Morning Lighting Enhancing Parasympathetic Activity at Night: A Pilot Study on Elderly Female Patients with Dementia without a Pacemaker.Healthcare (Basel, Switzerland) · 2023Article
- Overcoming treatment gaps in the management of depression with non-pharmacological adjunctive strategies.Frontiers in psychiatry · 2023Review
- Objective Measures of Immediate "Energizing" Effect of Light: Studies Review and Data Analysis.Clocks & sleep · 2022Review
- The Effect of Correlated Colour Temperature on Physiological, Emotional and Subjective Satisfaction in the Hygiene Area of a Space Station.International journal of environmental research and public health · 2022Article
- Effects of different light incident angles via a head-mounted device on the magnitude of nocturnal melatonin suppression in healthy young subjects.Sleep and biological rhythms · 2022Article
- Disruption of Circadian Rhythm Genes in Obstructive Sleep Apnea Patients-Possible Mechanisms Involved and Clinical Implication.International journal of molecular sciences · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Bright light therapy (BLT) is considered among the first-line treatments for seasonal affective disorder (SAD), yet a growing body of literature supports its use in other neuropsychiatric conditions including non-seasonal depression. Despite evidence of its antidepressant efficacy, clinical use of BLT remains highly variable internationally. In this article, we explore the autonomic effects of BLT and suggest that such effects may play a role in its antidepressant and chronotherapeutic properties. After providing a brief introduction on the clinical application of BLT, we review the chronobiological effects of BLT on depression and on the autonomic nervous system in depressed and non-depressed individuals with an emphasis on non-seasonal depression. Such a theory of autonomic modulation via BLT could serve to integrate aspects of recent work centered on alleviating allostatic load, the polyvagal theory, the neurovisceral integration model and emerging evidence on the roles of glutamate and gamma-hydroxybutyric acid (GABA).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.