Evidence map›Paper›PMID 24396593›Full record

ReviewAnemia2013

Beta-thalassemia major and female fertility: the role of iron and iron-induced oxidative stress.

Paraskevi Roussou, Nikolaos J Tsagarakis, Dimitrios Kountouras, Sarantis Livadas, Evanthia Diamanti-Kandarakis

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Anemia, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 62 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Observational
  10. Article
  11. Article
  12. Review
  13. Association of Beta-Thalassaemia and Hypogonadotropic Hypogonadism.Case reports in obstetrics and gynecology · 2022
    Article
  14. Review
  15. Consequences ofFrontiers in endocrinology · 2020
    Article
  16. Fertility in Patients with Thalassemia and Outcome of Pregnancies: A Turkish ExperienceTurkish journal of haematology : official journal of Turkish Society of Haematology · 2019
    Article
  17. Oocyte quality in women with thalassaemia major: insights from IVF cycles.European journal of obstetrics & gynecology and reproductive biology: X · 2019
    Article
  18. Article
  19. Pregnancy in women with thalassemia: challenges and solutions.International journal of women's health · 2016
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Paraskevi RoussouHematology Unit & Endocrine Unit, 3rd Department of Internal Medicine, Medical School, University of Athens, "Sotiria" General Hospital, 152 Mesogeion Avenue, 11527 Athens, Greece.
Nikolaos J TsagarakisHematology Unit & Endocrine Unit, 3rd Department of Internal Medicine, Medical School, University of Athens, "Sotiria" General Hospital, 152 Mesogeion Avenue, 11527 Athens, Greece.
Dimitrios KountourasHematology Unit & Endocrine Unit, 3rd Department of Internal Medicine, Medical School, University of Athens, "Sotiria" General Hospital, 152 Mesogeion Avenue, 11527 Athens, Greece.
Sarantis LivadasHematology Unit & Endocrine Unit, 3rd Department of Internal Medicine, Medical School, University of Athens, "Sotiria" General Hospital, 152 Mesogeion Avenue, 11527 Athens, Greece.
Evanthia Diamanti-KandarakisHematology Unit & Endocrine Unit, 3rd Department of Internal Medicine, Medical School, University of Athens, "Sotiria" General Hospital, 152 Mesogeion Avenue, 11527 Athens, Greece.
National and Kapodistrian University of Athens · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endocrine complications due to haemosiderosis are present in a significant number of patients with beta-thalassemia major (BTM) worldwide and often become barriers in their desire for parenthood. Thus, although spontaneous fertility can occur, the majority of females with BTM is infertile due to hypogonadotropic hypogonadism (HH) and need assisted reproductive techniques. Infertility in these women seems to be attributed to iron deposition and iron-induced oxidative stress (OS) in various endocrine organs, such as hypothalamus, pituitary, and female reproductive system, but also through the iron effect on other organs, such as liver and pancreas, contributing to the impaired metabolism of hormones and serum antioxidants. Nevertheless, the gonadal function of these patients is usually intact and fertility is usually retrievable. Meanwhile, a significant prooxidants/antioxidants imbalance with subsequent increased (OS) exists in patients with BTM, which is mainly caused by tissue injury due to overproduction of free radicals by secondary iron overload, but also due to alteration in serum trace elements and antioxidant enzymes. Not only using the appropriate antioxidants, essential trace elements, and minerals, but also regulating the advanced glycation end products, could probably reduce the extent of oxidative damage and related complications and retrieve BTM women's infertility.

Identifiers

PMID24396593
PMCPMC3876768
OpenAlexW2142798291

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.