ArticleBiomicrofluidics2013
An effective splitting-and-recombination micromixer with self-rotated contact surface for wide Reynolds number range applications.
Article in Biomicrofluidics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Lipid nanoparticle-mediated co-delivery of IL-33 mRNA and STING agonist modulates the breast cancer microenvironment and potentiates immunotherapy.Journal of nanobiotechnology · 2026Article
- Performance analysis of three-dimensional passive micromixers using k-means priority clustering with AHP-based sustainable design optimization.Scientific reports · 2025Article
- A PDMS-based Microfluidic Chip Assembly for Time-Resolved Cryo-EM (TRCEM) Sample Preparation.Bio-protocol · 2025Article
- Time-resolved cryo-EM (TRCEM) sample preparation using a PDMS-based microfluidic chip assembly.bioRxiv : the preprint server for biology · 2024Article
- Article
- Micromixing within microfluidic devices: Fundamentals, design, and fabrication.Biomicrofluidics · 2023Review
- Topology-Optimized Micromixer Design with Enhanced Reverse Flow to Increase Mixing Efficiency.Micromachines · 2023Article
- Modeling and simulation of a split and recombination-based passive micromixer with vortex-generating mixing units.Heliyon · 2023Article
- Design and High-Resolution Analysis of an Efficient Periodic Split-and-Recombination Microfluidic Mixer.Micromachines · 2022Article
- Characterization of Soft Tooling Photopolymers and Processes for Micromixing Devices with Variable Cross-Section.Micromachines · 2020Article
- A Review of Passive Micromixers with a Comparative Analysis.Micromachines · 2020Review
- Multifrequency Induced-Charge Electroosmosis.Micromachines · 2019Article
- A hybrid micromixer with planar mixing units.RSC advances · 2018Article
- Multi-Objective Optimizations of a Serpentine Micromixer with Crossing Channels at Low and High Reynolds Numbers.Micromachines · 2018Article
- A Review on Micromixers.Micromachines · 2017Review
- In-plane microvortices micromixer-based AC electrothermal for testing drug induced death of tumor cells.Biomicrofluidics · 2016Article
- A "twisted" microfluidic mixer suitable for a wide range of flow rate applications.Biomicrofluidics · 2016Article
- Effect of the crossing-structure sequence on mixing performance within three-dimensional micromixers.Biomicrofluidics · 2014Article
- Fabrication of nanochannels with ladder nanostructure at the bottom using AFM nanoscratching method.Nanoscale research letters · 2014Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is difficult to mix two liquids on a microfluidic chip because the small dimensions and velocities effectively prevent the turbulence. This paper describes two 2-layer PDMS passive micromixers based on the concept of splitting and recombining the flow that exploits a self-rotated contact surface to increase the concentration gradients to obtain fast and efficient mixing. The designed micromixers were simulated and the mixing performance was assessed. The mixers have shown excellent mixing efficiency over a wide range of Reynolds number. The mixers were reasonably fabricated by multilayer soft lithography, and the experimental measurements were performed to qualify the mixing performance of the realized mixer. The results show that the mixing efficiency for one realized mixer is from 91.8% to 87.7% when the Reynolds number increases from 0.3 to 60, while the corresponding value for another mixer is from 89.4% to 72.9%. It is rather interesting that the main mechanism for the rapid mixing is from diffusion to chaotic advection when the flow rate increases, but the mixing efficiency has not obvious decline. The smart geometry of the mixers with total length of 10.25 mm makes it possible to be integrated with many microfluidic devices for various applications in μ-TAS and Lab-on-a-chip systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.