ArticleBiomicrofluidics2013
Microfluidic immunomagnetic cell separation using integrated permanent micromagnets.
Article in Biomicrofluidics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- MagSculptor: A Microfluidic Platform for High-Resolution Magnetic Fractionation of Low-Expression Cell Subtypes.Biosensors · 2026Article
- Magnetic nanoparticles fabricated/integrated with microfluidics for biological applications: A review.Biomedical microdevices · 2024Review
- Liquid-based biomarkers in breast cancer: looking beyond the blood.Journal of translational medicine · 2023Review
- Liquid biopsy: current technology and clinical applications.Journal of hematology & oncology · 2022Review
- Optimal Halbach Configuration for Flow-through Immunomagnetic CTC Enrichment.Diagnostics (Basel, Switzerland) · 2021Article
- Eukaryotic Cell Capture by Amplified MagneticFrontiers in microbiology · 2021Article
- Magnetic Particles for CTC Enrichment.Cancers · 2020Review
- Article
- Magnetically driven microfluidics for isolation of circulating tumor cells.Cancer medicine · 2020Review
- A High-Throughput Microfluidic Magnetic Separation (µFMS) Platform for Water Quality Monitoring.Micromachines · 2019Article
- Label-free microfluidic chip for the identification of mesothelial cell clusters in pleural effusion.Oncology letters · 2019Article
- Microfluidic flow cytometry: The role of microfabrication methodologies, performance and functional specification.Technology · 2018Article
- How a High-Gradient Magnetic Field Could Affect Cell Life.Scientific reports · 2016Article
- Paramagnetic Structures within a Microfluidic Channel for Enhanced Immunomagnetic Isolation and Surface Patterning of Cells.Scientific reports · 2016Article
- Highly tunable perpendicularly magnetized synthetic antiferromagnets for biotechnology applications.Applied physics letters · 2015Article
- Simultaneous diamagnetic and magnetic particle trapping in ferrofluid microflows via a single permanent magnet.Biomicrofluidics · 2015Article
- Dual-mode on-demand droplet routing in multiple microchannels using a magnetic fluid as carrier phase.Biomicrofluidics · 2014Article
- Isolation of cells for selective treatment and analysis using a magnetic microfluidic chip.Biomicrofluidics · 2014Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this paper, we demonstrate the possibility to trap and sort labeled cells under flow conditions using a microfluidic device with an integrated flat micro-patterned hard magnetic film. The proposed technique is illustrated using a cell suspension containing a mixture of Jurkat cells and HEK (Human Embryonic Kidney) 293 cells. Prior to sorting experiments, the Jurkat cells were specifically labeled with immunomagnetic nanoparticles, while the HEK 293 cells were unlabeled. Droplet-based experiments demonstrated that the Jurkat cells were attracted to regions of maximum stray field flux density while the HEK 293 cells settled in random positions. When the mixture was passed through a polydimethylsiloxane (PDMS) microfluidic channel containing integrated micromagnets, the labeled Jurkat cells were selectively trapped under fluid flow, while the HEK cells were eluted towards the device outlet. Increasing the flow rate produced a second eluate much enriched in Jurkat cells, as revealed by flow cytometry. The separation efficiency of this biocompatible, compact micro-fluidic separation chamber was compared with that obtained using two commercial magnetic cell separation kits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.