ArticleBiomicrofluidics2013
Size-based hydrodynamic rare tumor cell separation in curved microfluidic channels.
Article in Biomicrofluidics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed.
- Suppressing Blood-Cell Migration Lag via Dean-Cycle Phase Regulation Enables High-Purity CTC Enrichment in an Inertial Microfluidic Array.Micromachines · 2026Article
- Evaluation of the Cellsway Microfluidic CTC Enrichment and Identification Platform for CTC Detection in Metastatic NSCLC.Biosensors · 2026Article
- A Universal and Single-Step (De)Molding Sorting Chip Integrating Inertial and Deterministic Lateral Displacement Units.Bioengineering (Basel, Switzerland) · 2025Article
- Effects of Shear and Extensional Stresses on Cells: Investigation in a Spiral Microchannel and Contraction-Expansion Arrays.ACS biomaterials science & engineering · 2025Review
- Analytical Validation of a Spiral Microfluidic Chip with Hydrofoil-Shaped Pillars for the Enrichment of Circulating Tumor Cells.Biosensors · 2023Article
- Flow study of Dean's instability in high aspect ratio microchannels.Scientific reports · 2023Article
- Separation of U87 glioblastoma cell-derived small and medium extracellular vesicles using elasto-inertial flow focusing (a spiral channel).Scientific reports · 2022Article
- Inertial-Assisted Immunomagnetic Bioplatform towards Efficient Enrichment of Circulating Tumor Cells.Biosensors · 2021Article
- Three step flow focusing enables image-based discrimination and sorting of late stage 1 Haematococcus pluvialis cells.PloS one · 2021Article
- A Novel Microfluidic Method Utilizing a Hydrofoil Structure to Improve Circulating Tumor Cell Enrichment: Design and Analytical Validation.Micromachines · 2020Article
- Scalable Signature-Based Molecular Diagnostics Through On-chip Biomarker Profiling Coupled with Machine Learning.Annals of biomedical engineering · 2020Review
- Fully-automated and field-deployable blood leukocyte separation platform using multi-dimensional double spiral (MDDS) inertial microfluidics.Lab on a chip · 2020Article
- A Review of Secondary Flow in Inertial Microfluidics.Micromachines · 2020Review
- Designing Microfluidic Devices to Sort Haematopoietic Stem Cells Based on Their Mechanical Properties.Stem cells international · 2019Article
- Assessment of Lagrangian Modeling of Particle Motion in a Spiral Microchannel for Inertial Microfluidics.Micromachines · 2018Article
- Progress of Inertial Microfluidics in Principle and Application.Sensors (Basel, Switzerland) · 2018Review
- A Microfluidic Chip with Double-Slit Arrays for Enhanced Capture of Single Cells.Micromachines · 2018Article
- Analysis of Hydrodynamic Mechanism on Particles Focusing in Micro-Channel Flows.Micromachines · 2017Article
- The advection of microparticles, MCF-7 and MDA-MB-231 breast cancer cells in response to very low Reynolds numbers.Biomicrofluidics · 2017Article
- Comparison of Chip Inlet Geometry in Microfluidic Devices for Cell Studies.Molecules (Basel, Switzerland) · 2016Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this work, we propose a rapid and continuous rare tumor cell separation based on hydrodynamic effects in a label-free manner. The competition between the inertial lift force and Dean drag force inside a double spiral microchannel results in the size-based cell separation of large tumor cells and small blood cells. The mechanism of hydrodynamic separation in curved microchannel was investigated by a numerical model. Experiments with binary mixture of 5- and 15-μm-diameter polystyrene particles using the double spiral channel showed a separation purity of more than 95% at the flow rate above 30 ml/h. High throughput (2.5 × 10(8) cells/min) and efficient cell separation (more than 90%) of spiked HeLa cells and 20 × diluted blood cells was also achieved by the double spiral channel.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.