ArticleCurrent genomics2013
Actin-associated Proteins in the Pathogenesis of Podocyte Injury.
Article in Current genomics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 33 citations in OpenAlex.
- Structural and functional insights of the podocyte slit diaphragm complex.Tissue barriers · 2026Review
- Multi-cellular network model predicts alterations in glomerular endothelial structure in diabetic kidney disease.PLoS computational biology · 2025Article
- Mechanisms and Therapeutic Perspectives of Podocyte Aging in Podocytopathies.International journal of molecular sciences · 2025Review
- Correlation analysis of cofilin-1 with renal prognosis in primary IgA nephropathy.BMC nephrology · 2024Article
- Klotho Stabilizes the Podocyte Actin Cytoskeleton in Idiopathic Membranous Nephropathy through Regulating the TRPC6/CatL Pathway.American journal of nephrology · 2024Article
- Article
- Detrimental effects of hypoxia on glomerular podocytes.Journal of physiology and biochemistry · 2021Review
- Mfn2 Regulates High Glucose-Induced MAMs Dysfunction and Apoptosis in PodocytesFrontiers in cell and developmental biology · 2021Article
- Article
- Triptolide potentiates the cytoskeleton-stabilizing activity of cyclosporine A in glomerular podocytesAmerican journal of translational research · 2020Article
- The TNF-derived TIP peptide activates the epithelial sodium channel and ameliorates experimental nephrotoxic serum nephritis.Kidney international · 2019Article
- Phosphoinositides in the kidney.Journal of lipid research · 2019Review
- Podocyte RhoGTPases: new therapeutic targets for nephrotic syndrome?F1000Research · 2019Review
- The role of B7-1 in proteinuria of glomerular origin.Nature reviews. Nephrology · 2018Review
- Article
- Blocking peptides and molecular mimicry as treatment for kidney disease.American journal of physiology. Renal physiology · 2017Review
- Functional validation of tensin2 SH2-PTB domain by CRISPR/Cas9-mediated genome editing.The Journal of veterinary medical science · 2016Article
- Disease-causing mutations of RhoGDIα induce Rac1 hyperactivation in podocytes.Small GTPases · 2016Article
- Secondary Focal Segmental Glomerulosclerosis: From Podocyte Injury to Glomerulosclerosis.BioMed research international · 2016Review
- From Glomerular Endothelium to Podocyte Pathobiology in Preeclampsia: a Paradigm Shift.Current hypertension reports · 2015Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Podocytes have a complex cellular architecture with interdigitating processes maintained by a precise organization of actin filaments. The actin-based foot processes of podocytes and the interposed slit diaphragm form the final barrier to proteinuria. The function of podocytes is largely based on the maintenance of the normal foot process structure with actin cytoskeleton. Cytoskeletal dynamics play important roles during normal podocyte development, in maintenance of the healthy glomerular filtration barrier, and in the pathogenesis of glomerular diseases. In this review, we focused on recent findings on the mechanisms of organization and reorganization of these actin-related molecules in the pathogenesis of podocyte injury and potential therapeutics targeting the regulation of actin cytoskeleton in podocytopathies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.