Evidence map›Paper›PMID 24396177›Full record

Trial reportCanadian journal of veterinary research = Revue canadienne de recherche veterinaire2014

Assessment of attenuated Salmonella vaccine strains in controlling experimental Salmonella Typhimurium infection in chickens.

Yanlong Pei, Valeria R Parreira, Kenneth L Roland, Roy Curtiss, John F Prescott

Open access · greenAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Canadian journal of veterinary research = Revue canadienne de recherche veterinaire, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Safety of theFrontiers in veterinary science · 2022
    Article
  4. Article
  5. Live Bacterial Prophylactics in Modern Poultry.Frontiers in veterinary science · 2020
    Review
  6. Oral Treatments With Probiotics and LiveFrontiers in microbiology · 2019
    Article
  7. Recent Advances in Vaccine Technologies.The Veterinary clinics of North America. Small animal practice · 2018
    Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Yanlong PeiDepartment of Pathobiology, University of Guelph, Guelph, Ontario N1G 2W1 (Pei, Parreira, Prescott); and The Biodesign Institute, Arizona State University, Tempe, Arizona 85287, USA (Roland, Curtiss).
Valeria R ParreiraDepartment of Pathobiology, University of Guelph, Guelph, Ontario N1G 2W1 (Pei, Parreira, Prescott); and The Biodesign Institute, Arizona State University, Tempe, Arizona 85287, USA (Roland, Curtiss).
Kenneth L RolandDepartment of Pathobiology, University of Guelph, Guelph, Ontario N1G 2W1 (Pei, Parreira, Prescott); and The Biodesign Institute, Arizona State University, Tempe, Arizona 85287, USA (Roland, Curtiss).
Roy CurtissDepartment of Pathobiology, University of Guelph, Guelph, Ontario N1G 2W1 (Pei, Parreira, Prescott); and The Biodesign Institute, Arizona State University, Tempe, Arizona 85287, USA (Roland, Curtiss).
John F PrescottDepartment of Pathobiology, University of Guelph, Guelph, Ontario N1G 2W1 (Pei, Parreira, Prescott); and The Biodesign Institute, Arizona State University, Tempe, Arizona 85287, USA (Roland, Curtiss).
University of Guelph · CA

Funding

Salmonella Vaccines Against Bacterial EnteropathogensR01AI060557 · NIAID · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI CURTISS III, ROY · 2010 to 2014
$2.2M
NIAID NIH HHS R01 AI060557
6 · The paper itself

Abstract

Salmonella hold considerable promise as vaccine delivery vectors for heterologous antigens in chickens. Such vaccines have the potential additional benefit of also controlling Salmonella infection in immunized birds. As a way of selecting attenuated strains with optimal immunogenic potential as antigen delivery vectors, this study screened 20 novel Salmonella Typhimurium vaccine strains, differing in mutations associated with delayed antigen synthesis and delayed attenuation, for their efficacy in controlling colonization by virulent Salmonella Typhimurium, as well as for their persistence in the intestine and the spleen. Marked differences were observed between strains in these characteristics, which provide the basis for selection for further study as vaccine vectors.

Indexed as

AnimalsBacterial SheddingCecumChickensFecesFemaleMalePoultry DiseasesSalmonella Infections, AnimalSalmonella typhimuriumSalmonella VaccinesSpleenVaccines, AttenuatedSalmonella VaccinesVaccines, Attenuated

Identifiers

PMID24396177
PMCPMC3878005
OpenAlexW254304229

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.