Evidence map›Paper›PMID 24396175›Full record

Trial reportCanadian journal of veterinary research = Revue canadienne de recherche veterinaire2014

A live-attenuated and an inactivated chimeric porcine circovirus (PCV)1-2 vaccine are both effective at inducing a humoral immune response and reducing PCV2 viremia and intrauterine infection in female swine of breeding age.

Michelle Hemann, Nathan M Beach, Xiang-Jin Meng, Chong Wang, Patrick G Halbur, Tanja Opriessnig

Abstract readRandomized Controlled Trial
PubMed Full text at PMC
In one paragraph

Trial report in Canadian journal of veterinary research = Revue canadienne de recherche veterinaire, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Michelle HemannDepartment of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine (Hemann, Wang, Halbur, Opriessnig) and Department of Statistics, College of Liberal Arts & Sciences, Iowa State University, Ames, Iowa, USA (Wang); Department of Biomedical Sciences and Pathobiology, Center for Molecular Medicine and Infectious Diseases, College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA (Beach, Meng); The Roslin Institute and The Royal (Dick) School of Veterinary Studies, University of Edinburgh, Midlothian, United Kingdom (Opriessnig).
Nathan M BeachDepartment of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine (Hemann, Wang, Halbur, Opriessnig) and Department of Statistics, College of Liberal Arts & Sciences, Iowa State University, Ames, Iowa, USA (Wang); Department of Biomedical Sciences and Pathobiology, Center for Molecular Medicine and Infectious Diseases, College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA (Beach, Meng); The Roslin Institute and The Royal (Dick) School of Veterinary Studies, University of Edinburgh, Midlothian, United Kingdom (Opriessnig).
Xiang-Jin MengDepartment of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine (Hemann, Wang, Halbur, Opriessnig) and Department of Statistics, College of Liberal Arts & Sciences, Iowa State University, Ames, Iowa, USA (Wang); Department of Biomedical Sciences and Pathobiology, Center for Molecular Medicine and Infectious Diseases, College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA (Beach, Meng); The Roslin Institute and The Royal (Dick) School of Veterinary Studies, University of Edinburgh, Midlothian, United Kingdom (Opriessnig).
Chong WangDepartment of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine (Hemann, Wang, Halbur, Opriessnig) and Department of Statistics, College of Liberal Arts & Sciences, Iowa State University, Ames, Iowa, USA (Wang); Department of Biomedical Sciences and Pathobiology, Center for Molecular Medicine and Infectious Diseases, College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA (Beach, Meng); The Roslin Institute and The Royal (Dick) School of Veterinary Studies, University of Edinburgh, Midlothian, United Kingdom (Opriessnig).
Patrick G HalburDepartment of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine (Hemann, Wang, Halbur, Opriessnig) and Department of Statistics, College of Liberal Arts & Sciences, Iowa State University, Ames, Iowa, USA (Wang); Department of Biomedical Sciences and Pathobiology, Center for Molecular Medicine and Infectious Diseases, College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA (Beach, Meng); The Roslin Institute and The Royal (Dick) School of Veterinary Studies, University of Edinburgh, Midlothian, United Kingdom (Opriessnig).
Tanja OpriessnigDepartment of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine (Hemann, Wang, Halbur, Opriessnig) and Department of Statistics, College of Liberal Arts & Sciences, Iowa State University, Ames, Iowa, USA (Wang); Department of Biomedical Sciences and Pathobiology, Center for Molecular Medicine and Infectious Diseases, College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA (Beach, Meng); The Roslin Institute and The Royal (Dick) School of Veterinary Studies, University of Edinburgh, Midlothian, United Kingdom (Opriessnig).

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The objective of this pilot study was to determine the efficacy of inactivated (1 or 2 dose) and live-attenuated chimeric porcine circovirus (PCV)1-2 vaccines in sows using the PCV2-spiked semen model. Thirty-five sows were randomly divided into 6 groups: negative and positive controls, 1 dose inactivated PCV1-2 vaccine challenged (1-VAC-PCV2), 2 dose inactivated PCV1-2 vaccine challenged (2-VAC-PCV2), 1 dose live-attenuated PCV1-2 vaccine unchallenged (1-LIVE-VAC), and 1 dose live-attenuated PCV1-2 vaccine challenged (1-LIVE-VAC-PCV2). The inactivated PCV1-2 vaccine induced higher levels of PCV2-specific antibodies in dams. All vaccination strategies provided good protection against PCV2 viremia in dams, whereas the majority of the unvaccinated sows were viremic. Four of the 35 dams became pregnant: a negative control, a positive control, a 2-VAC-PCV2 sow, and a 1-LIVE-VAC-PCV2 sow. The PCV2 DNA was detected in 100%, 67%, and 29% of the fetuses obtained from the positive control, inactivated vaccinated, or live-attenuated vaccinated dams, respectively. The PCV2 antigen in hearts was only detectable in the positive control litter (23% of the fetuses). The PCV1-2 DNA was detected in 29% of the fetuses in the litter from the 1-LIVE-VAC-PCV2 dam. Under the conditions of this pilot study, both vaccines protected against PCV2 viremia in breeding age animals; however, vertical transmission was not prevented.

Indexed as

AgingAnimalsCircoviridae InfectionsCircovirusFemaleImmunity, HumoralPregnancySwineUterine DiseasesVaccines, AttenuatedVaccines, InactivatedViral VaccinesViremiaVaccines, AttenuatedVaccines, InactivatedViral Vaccines

Identifiers

PMID24396175
PMCPMC3878016

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.