Evidence map›Paper›PMID 24396135›Full record

ReviewClinical microbiology reviews2014

Early-onset neonatal sepsis.

Kari A Simonsen, Ann L Anderson-Berry, Shirley F Delair, H Dele Davies

2 registry-linked trialsOpen access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Clinical microbiology reviews, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 439 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
439citing papers in PubMed, 5 pooled it
53.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05274776 naunknown statusnot on this mapstarted 2022, after this paper: background citation

Safely Reduce Newborn Antibiotic Exposure With the Early-onset Sepsis Calculator: a Cluster Randomized Study (EOS Calculator RCT)

TypeinterventionalSponsorprof. dr. Frans B. PlötzRan2022 to 2024Enrolled1,830ConditionsEarly-Onset Sepsis, Neonatal, EOSArmsEOS calculator
NCT05692128 unknown statusnot on this mapstarted 2023, after this paper: background citation

Frequency and Severity of Thrombocytopenia in Neonatal Sepsis

TypeobservationalSponsorAssiut UniversityRan2023 to 2024Enrolled50ConditionsNeonatal SepsisArmsHematological and chemistry tests
3 · Its place in the literature

Who cites it

439 citing papers in PubMed, 5 syntheses or guidelines pooled it, 963 citations in OpenAlex.

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  14. mBio · 2026
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  19. Duration of empiric antibiotic coverage for ruling out early-onset sepsis in neonates.Journal of perinatology : official journal of the California Perinatal Association · 2026
    Article
  20. Timely administration of antibiotics for neonatal sepsis in the neonatal intensive care unit: A quality improvement initiative.Journal of perinatology : official journal of the California Perinatal Association · 2026
    Article

379 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Kari A SimonsenDivision of Infectious Diseases, Department of Pediatrics, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Ann L Anderson-Berry
Shirley F Delair
H Dele Davies
University of Nebraska Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Early-onset sepsis remains a common and serious problem for neonates, especially preterm infants. Group B streptococcus (GBS) is the most common etiologic agent, while Escherichia coli is the most common cause of mortality. Current efforts toward maternal intrapartum antimicrobial prophylaxis have significantly reduced the rates of GBS disease but have been associated with increased rates of Gram-negative infections, especially among very-low-birth-weight infants. The diagnosis of neonatal sepsis is based on a combination of clinical presentation; the use of nonspecific markers, including C-reactive protein and procalcitonin (where available); blood cultures; and the use of molecular methods, including PCR. Cytokines, including interleukin 6 (IL-6), interleukin 8 (IL-8), gamma interferon (IFN-γ), and tumor necrosis factor alpha (TNF-α), and cell surface antigens, including soluble intercellular adhesion molecule (sICAM) and CD64, are also being increasingly examined for use as nonspecific screening measures for neonatal sepsis. Viruses, in particular enteroviruses, parechoviruses, and herpes simplex virus (HSV), should be considered in the differential diagnosis. Empirical treatment should be based on local patterns of antimicrobial resistance but typically consists of the use of ampicillin and gentamicin, or ampicillin and cefotaxime if meningitis is suspected, until the etiologic agent has been identified. Current research is focused primarily on development of vaccines against GBS.

Indexed as

HumansInfant, NewbornMortalityNorth AmericaSepsis

Identifiers

PMID24396135
PMCPMC3910904
OpenAlexW2119347566

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.