Trial reportThe Journal of physiology2014
Consequences of peripheral chemoreflex inhibition with low-dose dopamine in humans.
Trial report in The Journal of physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02587533 (Peripheral Chemoreflex/Arterial Baroreflex Interaction in Patients With Electrical Carotid Sinus Stimulation), which is not on this map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Peripheral Chemoreflex/Arterial Baroreflex Interaction in Patients With Electrical Carotid Sinus Stimulation
Who cites it
27 citing papers in PubMed, 44 citations in OpenAlex.
- Influence of low-dose dopamine on exercise in fibrosing interstitial lung disease.Experimental physiology · 2026Trial
- Effect of endothelin-1 on the blood pressure response to acute hypoxia and hyperoxia in healthy young men.Physiological reports · 2024Trial
- Role of the carotid chemoreceptors in insulin-mediated sympathoexcitation in humans.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Trial
- Reductions in carotid chemoreceptor activity with low-dose dopamine improves baroreflex control of heart rate during hypoxia in humans.Physiological reports · 2016Trial
- Peripheral chemoreflex inhibition with low-dose dopamine: new insight into mechanisms of extreme apnea.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Trial
- G Protein-Coupled Receptor in High-Altitude Diseases: Mechanistic Insights and Therapeutic Opportunities.MedComm · 2026Review
- Age-dependent remodelling of arterial chemoafferent innervation in hypertension.Cardiovascular research · 2025Article
- Peripheral chemoreflex restrains skeletal muscle blood flow during exercise in participants with treated hypertension.The Journal of physiology · 2025Article
- Autonomic and respiratory consequences of altered chemoreflex function: clinical and therapeutic implications in cardiovascular diseases.European journal of heart failure · 2023Review
- A Methodological Perspective on the Function and Assessment of Peripheral Chemoreceptors in Heart Failure: A Review of Data from Clinical Trials.Biomolecules · 2022Review
- Role of the Autonomic Nervous System in the Hemodynamic Response to Hyperinsulinemia-Implications for Obesity and Insulin Resistance.Current diabetes reports · 2022Review
- Inhibition of peripheral chemoreceptors improves ventilatory efficiency during exercise in heart failure with preserved ejection fraction - a role of tonic activity and acute reflex response.Frontiers in physiology · 2022Article
- The Role of Pharmacological Treatment in the Chemoreflex Modulation.Frontiers in physiology · 2022Review
- Acute hyperoxia reveals tonic influence of peripheral chemoreceptors on systemic vascular resistance in heart failure patients.Scientific reports · 2021Article
- Carotid body chemosensitivity is not attenuated during cold water diving.American journal of physiology. Regulatory, integrative and comparative physiology · 2021Article
- Carotid body chemosensitivity at 1.6 ATA breathing air versus 100% oxygen.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- Respiratory pattern and phrenic and hypoglossal nerve activity during normoxia and hypoxia in 6-OHDA-induced bilateral model of Parkinson's disease.The journal of physiological sciences : JPS · 2020Article
- Glucose, insulin, and the carotid body chemoreceptors in humans.Physiological genomics · 2018Review
- Effects of intravenous low-dose dopamine infusion on glucose regulation during prolonged aerobic exercise.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Article
- Peripheral chemosensitivity is not blunted during 2 h of thermoneutral head out water immersion in healthy men and women.Physiological reports · 2017Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Low-dose dopamine inhibits peripheral chemoreceptors and attenuates the hypoxic ventilatory response (HVR) in humans. However, it is unknown: (1) whether it also modulates the haemodynamic reactions to acute hypoxia, (2) whether it also modulates cardiac baroreflex sensitivity (BRS) and (3) if there is any effect of dopamine withdrawal. We performed a double-blind, placebo-controlled study on 11 healthy male volunteers. At sea level over 2 days every subject was administered low-dose dopamine (2 μg kg(-1) min(-1)) or saline infusion, during which we assessed both ventilatory and haemodynamic responses to acute hypoxia. Separately, we evaluated effects of initiation and withdrawal of each infusion and BRS. The initiation of dopamine infusion did not affect minute ventilation (MV) or mean blood pressure (MAP), but increased both heart rate (HR) and cardiac output. Concomitantly, it decreased systemic vascular resistance. Dopamine blunted the ventilatory, MAP and HR reactions (hypertension, tachycardia) to acute hypoxia. Dopamine attenuated cardiac BRS to falling blood pressure. Dopamine withdrawal evoked an increase in MV. The magnitude of the increment in MV due to dopamine withdrawal correlated with the size of the HVR and depended on the duration of dopamine administration. The ventilatory reaction to dopamine withdrawal constitutes a novel index of peripheral chemoreceptor function.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.