ReviewThe Journal of physiology2014
Integrative regulation of human brain blood flow.
Review in The Journal of physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 430 papers, 5 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
430 citing papers in PubMed, 5 syntheses or guidelines pooled it, 829 citations in OpenAlex.
- On the mechanisms of brain blood flow regulation during hypoxia.The Journal of physiology · 2025Pooled it
- Physiological influences on neurovascular coupling: A systematic review of multimodal imaging approaches and recommendations for future study designs.Experimental physiology · 2025Pooled it
- Associations of Cerebrovascular Regulation and Arterial Stiffness With Cerebral Small Vessel Disease: A Systematic Review and Meta-Analysis.Journal of the American Heart Association · 2023Pooled it
- Tale of Two Cities: narrative review of oxygen.F1000Research · 2023Pooled it
- The Use of Near-Infrared Spectroscopy and/or Transcranial Doppler as Non-Invasive Markers of Cerebral Perfusion in Adult Sepsis Patients With Delirium: A Systematic Review.Journal of intensive care medicine · 2022Pooled it
- Impact of Different Pneumoperitoneum Pressures on Internal Carotid Artery Blood Flow and Cerebral Oxygenation in Laparoscopic Sleeve Gastrectomy.Obesity surgery · 2026Trial
- Feasibility of superimposed supine cycling and lower body negative pressure as an effective means of prolonging exercise tolerance in individuals experiencing persisting post-concussive symptoms: Preliminary results.Experimental physiology · 2026Trial
- On-feet isometric bracing maintains cerebral arterial blood velocity during lower body negative pressure via preload augmentation.Experimental physiology · 2026Trial
- Effects of ultrasound-guided stellate ganglion block in poststroke bulbar palsy: a double-blind placebo-controlled trial.BMC medicine · 2026Trial
- Evaluation of the effects of Plasma-Lyte 148 or 0.9% saline on acid-base balance in patients undergoing neurosurgery: a randomized clinical trial.Einstein (Sao Paulo, Brazil) · 2026Trial
- Hemorheological, cardiorespiratory, and cerebrovascular effects of pentoxifylline following acclimatization to 3,800 m.American journal of physiology. Heart and circulatory physiology · 2024Trial
- Effects of intermittent exercise during prolonged sitting on executive function, cerebrovascular, and psychological response: a randomized crossover trial.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Trial
- Fat Consumption Attenuates Cortical Oxygenation during Mental Stress in Young Healthy Adults.Nutrients · 2023Trial
- The Effect of a Neuronal Nitric Oxide Synthase Inhibitor on Neurovascular Regulation in Humans.Circulation research · 2022Trial
- Association between cardiorespiratory fitness and cerebrovascular reactivity to a breath-hold stimulus in older adults: influence of aerobic exercise training.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Trial
- Effect of lactate administration on cerebral blood flow during hypoglycemia in people with type 1 diabetes.BMJ open diabetes research & care · 2022Trial
- Exogenous ketosis in breath-hold diving: Promise, paradox and physiological risk.Experimental physiology · 2026Review
- Aortic Longitudinal Stretch and Recoil Affect Cerebral Perfusion: Insights from a Physiologically Accurate In-Vitro Experiment Model.Annals of biomedical engineering · 2026Article
- Automated estimation of the logistic curve model of cerebral COJournal of clinical monitoring and computing · 2026Article
- Regional changes in cerebral blood flow between the upright and supine posture and over 3 days of bed rest.Experimental physiology · 2026Article
370 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Herein, we review mechanisms regulating cerebral blood flow (CBF), with specific focus on humans. We revisit important concepts from the older literature and describe the interaction of various mechanisms of cerebrovascular control. We amalgamate this broad scope of information into a brief review, rather than detailing any one mechanism or area of research. The relationship between regulatory mechanisms is emphasized, but the following three broad categories of control are explicated: (1) the effect of blood gases and neuronal metabolism on CBF; (2) buffering of CBF with changes in blood pressure, termed cerebral autoregulation; and (3) the role of the autonomic nervous system in CBF regulation. With respect to these control mechanisms, we provide evidence against several canonized paradigms of CBF control. Specifically, we corroborate the following four key theses: (1) that cerebral autoregulation does not maintain constant perfusion through a mean arterial pressure range of 60-150 mmHg; (2) that there is important stimulatory synergism and regulatory interdependence of arterial blood gases and blood pressure on CBF regulation; (3) that cerebral autoregulation and cerebrovascular sensitivity to changes in arterial blood gases are not modulated solely at the pial arterioles; and (4) that neurogenic control of the cerebral vasculature is an important player in autoregulatory function and, crucially, acts to buffer surges in perfusion pressure. Finally, we summarize the state of our knowledge with respect to these areas, outline important gaps in the literature and suggest avenues for future research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.