ArticleThe Journal of physiology2014
Kainate receptor subunit diversity underlying response diversity in retinal off bipolar cells.
Article in The Journal of physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 56 citations in OpenAlex.
- The Retinal Light Response Is Modulated by an mGluR5-Mediated Retrograde Signal from ON-Bipolar Cells to Photoreceptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Single-Cell Transcriptomics onBiomedicines · 2025Article
- The retinal light response is modulated by an mGluR5-mediated retrograde signal from ON-bipolar cells to photoreceptors.bioRxiv : the preprint server for biology · 2025Article
- Article
- Mechanisms of simultaneous linear and nonlinear computations at the mammalian cone photoreceptor synapse.Nature communications · 2023Article
- Dye coupling of horizontal cells in the primate retina.Frontiers in ophthalmology · 2023Article
- Using optogenetics to dissect rod inputs to OFF ganglion cells in the mouse retina.Frontiers in ophthalmology · 2023Article
- Review
- A theoretical model reveals specialized synaptic depressions and temporal frequency tuning in retinal parallel channels.Frontiers in computational neuroscience · 2022Article
- An uncommon neuronal class conveys visual signals from rods and cones to retinal ganglion cells.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Clustered mutations in the GRIK2 kainate receptor subunit gene underlie diverse neurodevelopmental disorders.American journal of human genetics · 2021Article
- Development and maintenance of vision's first synapse.Developmental biology · 2021Review
- Computational and Molecular Properties of Starburst Amacrine Cell Synapses Differ With Postsynaptic Cell Type.Frontiers in cellular neuroscience · 2021Article
- Ground squirrel - A cool model for a bright vision.Seminars in cell & developmental biology · 2020Review
- ERG Responses in Mice with Deletion of the Synaptic Ribbon Component RIBEYE.Investigative ophthalmology & visual science · 2020Article
- Dopaminergic Modulation of Signal Processing in a Subset of Retinal Bipolar Cells.Frontiers in cellular neuroscience · 2020Article
- Diverse Cell Types, Circuits, and Mechanisms for Color Vision in the Vertebrate Retina.Physiological reviews · 2019Review
- Using Looming Visual Stimuli to Evaluate Mouse Vision.Journal of visualized experiments : JoVE · 2019Article
- GRIK5 Genetically Regulated Expression Associated with Eye and Vascular Phenomes: Discovery through Iteration among Biobanks, Electronic Health Records, and Zebrafish.American journal of human genetics · 2019Article
- Selective synaptic connections in the retinal pathway for night vision.The Journal of comparative neurology · 2019Article
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4 authors at 1 institution in 1 country.
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Abstract
Postsynaptic kainate receptors mediate excitatory synaptic transmission over a broad range of temporal frequencies. In heterologous systems, the temporal responses of kainate receptors vary when different channel-forming and auxiliary subunits are co-expressed but how this variability relates to the temporal differences at central synapses is incompletely understood. The mammalian cone photoreceptor synapse provides advantages for comparing the different temporal signalling roles of kainate receptors, as cones release glutamate over a range of temporal frequencies, and three functionally distinct Off bipolar cell types receive cone signals at synapses that contain either AMPA or kainate receptors, all with different temporal properties. A disadvantage is that the different receptor subunits are not identified. We used in situ hybridization, immunocytochemistry, and pharmacology to identify the kainate receptor and auxiliary subunits in ground squirrel (Ictidomys tridecimlineatus) cb1a/b, cb2, and cb3a/b Off bipolar cell types. As expected, the types showed distinct subunit expression patterns. Kainate receptors mediated ∼80% of the synaptic response in cb3a/b cells and were heteromers of GluK1 and GluK5. Cb3a/b cells contained message for GluK1 and GluK5, and also GluK3 and the auxiliary subunit Neto1. The synaptic responses in cb1a/b cells were mediated by GluK1-containing kainate receptors that behaved differently from the receptors expressed by cb3a/b cells. AMPA receptors mediated the entire synaptic response in cb2 cells and the remaining synaptic response in cb3a/b cells. We conclude that GluK1 is the predominant kainate receptor subunit in cb1 and cb3 Off bipolar cells. Different temporal response properties may result from selective association with GluK3, GluK5, or Neto1.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.