ArticleInfection and immunity2014
TREM-1 promotes survival during Klebsiella pneumoniae liver abscess in mice.
Article in Infection and immunity, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 33 citations in OpenAlex.
- Phosphorylation Modification Characteristics of Liver Injury-Related Proteins inPathogens (Basel, Switzerland) · 2026Article
- Co-evolution of resistance and virulence inFrontiers in cellular and infection microbiology · 2026Review
- Triggering Receptor Expressed on Myeloid Cells-1 (TREM-1) in Inflammation and Disease: Mechanisms, Therapeutic Potential, and Future Directions.International journal of molecular sciences · 2025Review
- Genetic and immune determinants ofProceedings of the National Academy of Sciences of the United States of America · 2023Article
- The biology of TREM receptors.Nature reviews. Immunology · 2023Review
- Genetic and immune determinants ofbioRxiv : the preprint server for biology · 2023Article
- SiderophoreBiochemistry and biophysics reports · 2022Article
- Reduced Uterine Tissue Damage during Chlamydia muridarum Infection in TREM-1,3-Deficient Mice.Infection and immunity · 2021Article
- Triggering Receptor Expressed on Myeloid Cells-1 (TREM-1) Contributes to Bordetella pertussis Inflammatory Pathology.Infection and immunity · 2021Article
- Surface TREM-1 as a Prognostic Biomarker in Pediatric Sepsis.Indian journal of pediatrics · 2021Observational
- Deoxycholic Acid and Lithocholic Acid Alleviate Liver Injury and Inflammation in Mice withJournal of inflammation research · 2021Article
- Triggering Receptor Expressed on Myeloid Cells-1 Agonist Regulates Intestinal Inflammation via Cd177Frontiers in immunology · 2021Article
- Identification of Dendritic Cell Maturation, TLR, and TREM1 Signaling Pathways in theFrontiers in veterinary science · 2021Article
- Gut Microbiota Contributes to Host Defense AgainstJournal of inflammation research · 2021Article
- Excessive Neutrophils and Neutrophil Extracellular Traps in COVID-19.Frontiers in immunology · 2020Article
- CelB is a suitable marker for rapid and specific identification of Klebsiella pneumoniae by the loop-mediated isothermal amplification (LAMP) assay.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2019Article
- TREM-1-dependent M1 macrophage polarization restores intestinal epithelium damaged by DSS-induced colitis by activating IL-22-producing innate lymphoid cells.Journal of biomedical science · 2019Article
- Triggering Receptor Expressed on Myeloid Cells-1 Signaling: Protective and Pathogenic Roles on Streptococcal Toxic-Shock-Like Syndrome Caused byFrontiers in immunology · 2018Review
- Single versus combined immunoregulatory approach using PD-1 and CTLA-4 modulators in controlling sepsis.Expert review of clinical immunology · 2017Review
- Identification of Extracellular Actin As a Ligand for Triggering Receptor Expressed on Myeloid Cells-1 Signaling.Frontiers in immunology · 2017Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Klebsiella pneumoniae liver abscess (KPLA) is prevalent in East Asia. Liver abscess can develop after translocation of K. pneumoniae from a patient's bowel into the liver via the portal circulation. TREM-1 (triggering receptor expressed on myeloid cells 1) amplifies inflammatory signaling during infection, but its role in KPLA is poorly understood. We used an animal study to characterize the role of TREM-1 in KPLA. We compared survival rates, bacterial burdens in tissues, inflammatory cytokine levels, and histology findings between wild-type and Trem-1 knockout (KO) mice after oral inoculation of capsular type K1 K. pneumoniae. Translocation of K. pneumoniae to mesenteric lymph nodes and liver was examined, and intestinal permeability, antimicrobial peptide expression, and the clearance of K. pneumoniae in the small intestine were determined. In the absence of TREM-1, KPLA model mice showed increased K. pneumoniae dissemination, enhanced liver and systemic inflammation, and reduced survival. Impaired bacterial clearance in the small intestine causes enhanced K. pneumoniae translocation, which renders Trem-1 KO mice more susceptible to K. pneumoniae oral infection. In conclusion, TREM-1-mediated bacterial clearance in the small intestine is an important immune response against K. pneumoniae. TREM-1 deficiency enhances K. pneumoniae translocation in the small intestine and increases mortality rates in mice with KPLA.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.