ArticleSocial cognitive and affective neuroscience2014
Neural disruption to theory of mind predicts daily social functioning in individuals at familial high-risk for schizophrenia.
Article in Social cognitive and affective neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Neural and behavioral effects of oxytocin administration during theory of mind in schizophrenia and controls: a randomized control trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Trial
- Individuals with High Social Anhedonia but not Schizophrenia Exhibited Altered Empathy in Daily Life.Schizophrenia bulletin · 2026Article
- Contributions of the posterior cerebellum to mentalizing and social functioning: A transdiagnostic investigation.Psychological medicine · 2025Article
- Neural mechanisms underlying reward processing and social cognition: A replication study with a Japanese sample.PloS one · 2025Article
- Symptoms of Attenuated Psychosis Syndrome in Relatives of Clinical High-Risk Youth: Preliminary Evidence.Schizophrenia bulletin · 2023Article
- Cerebellar correlates of social dysfunction among individuals at clinical high risk for psychosis.Frontiers in psychiatry · 2022Article
- The representation of mental state information in schizophrenia and first-degree relatives: a multivariate pattern analysis of fMRI data.Social cognitive and affective neuroscience · 2021Article
- Article
- Neural Correlates of Mentalizing in Individuals With Clinical High Risk for Schizophrenia: ALE Meta-Analysis.Frontiers in psychiatry · 2021Review
- The Neural Basis of Social Cognition in Typically Developing Children and Its Relationship to Social Functioning.Frontiers in psychology · 2021Article
- Machine learning identifies unaffected first-degree relatives with functional network patterns and cognitive impairment similar to those of schizophrenia patients.Human brain mapping · 2019Article
- Thinking about others and the future: Neural correlates of perspective taking relate to preferences for delayed rewards.Cognitive, affective & behavioral neuroscience · 2018Article
- Altered Neural Activity during Irony Comprehension in Unaffected First-Degree Relatives of Schizophrenia Patients-An fMRI Study.Frontiers in psychology · 2017Article
- Theory-of-mind-related neural activity for one's romantic partner predicts partner well-being.Social cognitive and affective neuroscience · 2016Article
- Theory of mind network activity is altered in subjects with familial liability for schizophrenia.Social cognitive and affective neuroscience · 2016Article
- F-18 fluorodeoxyglucose positron emission tomography study of impaired emotion processing in first episode schizophrenia.Schizophrenia research · 2015Article
- The relationship between default mode network connectivity and social functioning in individuals at familial high-risk for schizophrenia.Schizophrenia research · 2014Article
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3 authors.
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Abstract
Theory-of-mind (ToM) ability is foundational for successful social relationships, and dependent on a neurocognitive system, which includes temporoparietal junction and medial prefrontal cortex. Schizophrenia is associated with ToM impairments, and initial studies demonstrate similar, though more subtle deficits, in unaffected first-degree relatives, indicating that ToM deficits are a potential biomarker for the disorder. Importantly, the social consequences of ToM deficits could create an additional vulnerability factor for individuals at familial high risk (FHR). However, behavioral studies of ToM are inconsistent and virtually nothing is known about the neural basis of ToM in FHR or the relationship between ToM and social functioning. Here, FHR and non-FHR control participants underwent functional MRI scanning while reasoning about a story character's thoughts, emotions or physical appearance. Afterwards, participants completed a 28-day online 'daily-diary' questionnaire in which they reported daily social interactions and degree of ToM reasoning. FHR participants demonstrated less neural activity in bilateral temporoparietal junction when reasoning about thoughts and emotions. Moreover, across all participants, the degree of neural activity during ToM reasoning predicted several aspects of daily social behavior. Results suggest that vulnerability for schizophrenia is associated with neurocognitive deficits in ToM and the degree of deficit is related to day-to-day social functioning.
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