ArticleSocial cognitive and affective neuroscience2014
Evidence for a role of the oxytocin system, indexed by genetic variation in CD38, in the social bonding effects of expressed gratitude.
Article in Social cognitive and affective neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.
- The impact of gratitude interventions on patients with cardiovascular disease: a systematic review.Frontiers in psychology · 2023Pooled it
- Implementation intentions to express gratitude increase daily time co-present with an intimate partner, and moderate effects of variation in CD38.Scientific reports · 2022Trial
- Interparental Positivity Spillover Theory: How Parents' Positive Relational Interactions Influence Children.Perspectives on psychological science : a journal of the Association for Psychological Science · 2025Review
- Relationship power attenuated the effects of gratitude on perceived partner responsiveness and satisfaction in romantic relationships.Scientific reports · 2024Article
- Genetic Variations in Elements of the Oxytocinergic Pathway are Associated with Attention/Hyperactivity Problems and Anxiety Problems in Childhood.Child psychiatry and human development · 2024Article
- CD38 genetic variation is associated with increased personal distress to an emotional stimulus.Scientific reports · 2024Article
- A Scientometric Review of Infant Cry and Caregiver Responsiveness: Literature Trends and Research Gaps over 60 Years of Developmental Study.Children (Basel, Switzerland) · 2023Review
- Genetic and epigenetic effects on couple adjustment in context of romantic relationship: A scoping systematic review.Frontiers in genetics · 2023Article
- Enjoying the sweet moments: Does approach motivation upwardly enhance reactivity to positive interpersonal processes?Journal of personality and social psychology · 2022Article
- Neural mechanisms of social learning and decision-making.Science China. Life sciences · 2021Review
- CD38 is associated with bonding-relevant cognitions and relationship satisfaction over the first 3 years of marriage.Scientific reports · 2021Observational
- Cross-Cultural Nomological Network of Gratitude: Findings From Midlife in the United States (MIDUS) and Japan (MIDJA).Frontiers in psychology · 2020Article
- A role for theThe American journal of drug and alcohol abuse · 2020Article
- Mixed support for a causal link between single dose intranasal oxytocin and spiritual experiences: opposing effects depending on individual proclivities for absorption.Social cognitive and affective neuroscience · 2018Article
- The Oxytocin Receptor Gene (Frontiers in psychology · 2018Article
- Influences of oxytocin and respiratory sinus arrhythmia on emotions and social behavior in daily life.Emotion (Washington, D.C.) · 2017Article
- Oxytocin and Social Bonds: The Role of Oxytocin in Perceptions of Romantic Partners' Bonding Behavior.Psychological science · 2017Article
- The Cultivation of Pure Altruism via Gratitude: A Functional MRI Study of Change with Gratitude Practice.Frontiers in human neuroscience · 2017Article
- Effect of Transcranial Direct Current Stimulation of the Medial Prefrontal Cortex on the Gratitude of Individuals with Heterogeneous Ability in an Experimental Labor Market.Frontiers in behavioral neuroscience · 2017Article
- A Potential Role for mu-Opioids in Mediating the Positive Effects of Gratitude.Frontiers in psychology · 2017Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Oxytocin is thought to play a central role in promoting close social bonds via influence on social interactions. The current investigation targeted interactions involving expressed gratitude between members of romantic relationships because recent evidence suggests gratitude and its expression provides behavioral and psychological 'glue' to bind individuals closer together. Specifically, we took a genetic approach to test the hypothesis that social interactions involving expressed gratitude would be associated with variation in a gene, CD38, which has been shown to affect oxytocin secretion. A polymorphism (rs6449182) that affects CD38 expression was significantly associated with global relationship satisfaction, perceived partner responsiveness and positive emotions (particularly love) after lab-based interactions, observed behavioral expression of gratitude toward a romantic partner in the lab, and frequency of expressed gratitude in daily life. A separate polymorphism in CD38 (rs3796863) previously associated with plasma oxytocin levels and social engagement was also associated with perceived responsiveness in the benefactor after an expression of gratitude. The combined influence of the two polymorphisms was associated with a broad range of gratitude-related behaviors and feelings. The consistent pattern of findings suggests that the oxytocin system is associated with solidifying the glue that binds adults into meaningful and important relationships.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.