ArticleProceedings of the National Academy of Sciences of the United States of America2014
High-resolution lesion-mapping strategy links a hot spot in rat insular cortex with impaired expression of taste aversion learning.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 41 citations in OpenAlex.
- Comparative insights into insula structure and function.Nature neuroscience · 2026Review
- Neural coding in gustatory cortex reflects consumption decisions: evidence from conditioned taste aversion.Frontiers in systems neuroscience · 2026Article
- Insular cortex predictions regulate glucose homeostasis.bioRxiv : the preprint server for biology · 2025Article
- Savoring Satiety: An Exploratory Analysis of the Neural Correlates of Sensory-Specific Satiety.Nutrients · 2025Article
- Bilateral insular cortical lesions reduce sensitivity to the adverse consequences of acute ethanol intoxication in Pavlovian conditioning procedures.Alcohol, clinical & experimental research · 2024Article
- Escalation of alcohol intake is associated with regionally decreased insular cortex activity but not changes in taste quality.Alcohol, clinical & experimental research · 2023Article
- Projections of the insular cortex to orbitofrontal and medial prefrontal cortex: A tracing study in the rat.Frontiers in neuroanatomy · 2023Article
- Cellular activity in insular cortex across seconds to hours: Sensations and predictions of bodily states.Neuron · 2021Review
- Better living through understanding the insula: Why subregions can make all the difference.Neuropharmacology · 2021Review
- Dissociable control of μ-opioid-driven hyperphagia vs. food impulsivity across subregions of medial prefrontal, orbitofrontal, and insular cortex.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Intraperitoneal injection of lithium chloride induces lateralized activation of the insular cortex in adult mice.Molecular brain · 2021Article
- Rethinking the role of taste processing in insular cortex and forebrain circuits.Current opinion in physiology · 2021Article
- 'Liking' and 'wanting' in eating and food reward: Brain mechanisms and clinical implications.Physiology & behavior · 2020Review
- Chemospecific deficits in taste sensitivity following bilateral or right hemispheric gustatory cortex lesions in rats.The Journal of comparative neurology · 2020Article
- Recognizing Taste: Coding Patterns Along the Neural Axis in Mammals.Chemical senses · 2019Review
- The Functional and Neurobiological Properties of Bad Taste.Physiological reviews · 2019Review
- Nicotine pre-treatment reduces sensitivity to the interoceptive stimulus effects of commonly abused drugs as assessed with taste conditioning paradigms.Drug and alcohol dependence · 2019Article
- The role of the gustatory cortex in incidental experience-evoked enhancement of later taste learning.Learning & memory (Cold Spring Harbor, N.Y.) · 2018Article
- Distribution of Fos-immunoreactive neurons in the gustatory cortex elicited by intra-oral infusion of taste solutions in conscious rats.Brain research · 2018Article
- Opioid and orexin hedonic hotspots in rat orbitofrontal cortex and insula.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
Abstract
Gustatory cortex (GC), an assemblage of taste-responsive neurons in insular cortex, is widely regarded as integral to conditioned taste aversion (CTA) retention, a link that has been primarily established using lesion approaches in rats. In contrast to this prevailing view, we found that even the most complete bilateral damage to GC produced by ibotenic acid was insufficient to disrupt postsurgical expression of a presurgical CTA; nor were such lesions sufficient to disrupt postsurgical acquisition and initial expression of a second CTA. However, some rats with lesions were significantly impaired on these tests. Further examination of all conditioned rats with lesions, regardless of the lesion topography, revealed a significant positive association between damage in the posterior portion of GC and especially within adjacent posterior regions of insular cortex. Accordingly, we developed a high-resolution lesion-mapping program that permitted the overlay of the individual lesion maps from rats with CTA impairments to produce a groupwise aggregate lesion map. Comparison of this map with one derived from the unimpaired counterparts indicated a specific lesion "hot spot" associated with CTA deficits that included the most posterior end of GC and overlying granular layer and encompassed an area provisionally referred to in the literature as visceral cortex. Thus, the detailed mapping of the lesion in behaviorally defined subgroups of rats allowed us to exploit the variability in performance to uncloak an important potential component of the functional topography of insular cortex; such an approach could have general applicability to other brain structure-function endeavors as well.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.