ArticleProceedings of the National Academy of Sciences of the United States of America2014
SAD kinases control the maturation of nerve terminals in the mammalian peripheral and central nervous systems.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- Haploinsufficiency of brain-specific kinase BRSK1 causes epilepsy and neurodevelopmental disorders.Epilepsia · 2025Article
- A directionally evolved genomic feature in BRSK2 harbors divergent alleles in neurocognitive disorders.Scientific reports · 2025Article
- Brain-specific serine/threonine-protein kinase 1 is a substrate of protein kinase C epsilon involved in sex-specific ethanol and anxiety phenotypes.Addiction biology · 2024Article
- SAD-1 kinase controls presynaptic phase separation by relieving SYD-2/Liprin-α autoinhibition.PLoS biology · 2023Article
- Dynamic Regulation ofInternational journal of molecular sciences · 2023Article
- Case report: A novel frameshift mutation in BRSK2 causes autism in a 16-year old Chinese boy.Frontiers in psychiatry · 2023Article
- Deleterious Variation in BR Serine/Threonine Kinase 2 Classified a Subtype of Autism.Frontiers in molecular neuroscience · 2022Article
- Gain-of-function genetic screen of the kinome reveals BRSK2 as an inhibitor of the NRF2 transcription factor.Journal of cell science · 2020Article
- SAD-B modulates epileptic seizure by regulating AMPA receptors in patients with temporal lobe epilepsy and in the PTZ-induced epileptic model.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2020Article
- Isozyme-Specific Role of SAD-A in Neuronal Migration During Development of Cerebral Cortex.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- PAR3-PAR6-atypical PKC polarity complex proteins in neuronal polarization.Cellular and molecular life sciences : CMLS · 2018Review
- Versatile Roles of LKB1 Kinase Signaling in Neural Development and Homeostasis.Frontiers in molecular neuroscience · 2018Article
- The loss of the kinases SadA and SadB results in early neuronal apoptosis and a reduced number of progenitors.PloS one · 2018Article
- Identification of Upstream Kinases by Fluorescence Complementation Mass Spectrometry.ACS central science · 2017Article
- Developmental plasticity shapes synaptic phenotypes of autism-associated neuroligin-3 mutations in the calyx of Held.Molecular psychiatry · 2017Article
- Synapse Formation in Monosynaptic Sensory-Motor Connections Is Regulated by Presynaptic Rho GTPase Cdc42.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Genome-Wide Association of Heroin Dependence in Han Chinese.PloS one · 2016Article
- Structural insight into the mechanism of synergistic autoinhibition of SAD kinases.Nature communications · 2015Article
- Polarized activities of AMPK and BRSK in primary hippocampal neurons.Molecular biology of the cell · 2015Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Axons develop in a series of steps, beginning with specification, outgrowth, and arborization, and terminating with formation and maturation of presynaptic specializations. We found previously that the SAD-A and SAD-B kinases are required for axon specification and arborization in subsets of mouse neurons. Here, we show that following these steps, SAD kinases become localized to synaptic sites and are required within presynaptic cells for structural and functional maturation of synapses in both peripheral and central nervous systems. Deleting SADs from sensory neurons can perturb either axonal arborization or nerve terminal maturation, depending on the stage of deletion. Thus, a single pair of kinases plays multiple, sequential roles in axonal differentiation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.