ArticleProceedings of the National Academy of Sciences of the United States of America2014
Environmental enrichment extends ocular dominance plasticity into adulthood and protects from stroke-induced impairments of plasticity.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.
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81 citing papers in PubMed, 154 citations in OpenAlex.
- Complex Three-Dimensional Rearing Environments Amplify Compensatory Plasticity Following Early Blindness.eNeuro · 2026Article
- Protocol for recording visual maps in the mouse superior colliculus and visual cortex with intrinsic optical imaging.STAR protocols · 2026Article
- Visual experience drives functional reorganization of cortical GABAergic circuits.bioRxiv : the preprint server for biology · 2026Article
- Experience-dependent maturation of somatosensory parvalbumin interneurons during social development in prairie voles.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Investigating hierarchical critical periods in human neurodevelopment.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- A Scoping Review of Preclinical Environmental Enrichment Protocols in Models of Poststroke to Set the Foundations for Translating the Paradigm to Clinical Settings.Translational stroke research · 2025Article
- Adolescent maturation of dorsolateral prefrontal cortex glutamate:GABA and cognitive function is supported by dopamine-related neurobiology.Molecular psychiatry · 2025Article
- GABAergic signaling by VIP interneurons gates running-dependent visual recovery in the adult brain.bioRxiv : the preprint server for biology · 2025Article
- Multisensory integration, brain plasticity and optogenetics in visual rehabilitation.Frontiers in neurology · 2025Review
- Understanding amblyopia from the perspective of neurovascular units: changes in the retina and brain.Frontiers in cell and developmental biology · 2025Review
- Critical period plasticity is associated with resilience to short unpredictable stress.Frontiers in behavioral neuroscience · 2025Review
- From molecules to behavior: Implications for perineuronal net remodeling in learning and memory.Journal of neurochemistry · 2024Review
- Adolescent environmental enrichment induces social resilience and alters neural gene expression in a selectively bred rodent model with anxious phenotype.Neurobiology of stress · 2024Article
- Adolescent environmental enrichment induces social resilience and alters neural gene expression in a selectively bred rodent model with anxious phenotype.bioRxiv : the preprint server for biology · 2024Article
- Cognitive synaptopathy: synaptic and dendritic spine dysfunction in age-related cognitive disorders.Frontiers in aging neuroscience · 2024Review
- Environmental enrichment enhanced neurogenesis and behavioral recovery after stroke in aged rats.Aging · 2023Article
- Experience dependent plasticity of higher visual cortical areas in the mouse.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Article
- Enriched environment exposure during development positively impacts the structure and function of the visual cortex in mice.Scientific reports · 2023Article
- Enriched binocular experience followed by sleep optimally restores binocular visual cortical responses in a mouse model of amblyopia.Communications biology · 2023Article
21 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ocular dominance (OD) plasticity in mouse primary visual cortex (V1) declines during postnatal development and is absent beyond postnatal day 110 if mice are raised in standard cages (SCs). An enriched environment (EE) promotes OD plasticity in adult rats. Here, we explored cellular mechanisms of EE in mouse V1 and the therapeutic potential of EE to prevent impairments of plasticity after a cortical stroke. Using in vivo optical imaging, we observed that monocular deprivation in adult EE mice (i) caused a very strong OD plasticity previously only observed in 4-wk-old animals, (ii) restored already lost OD plasticity in adult SC-raised mice, and (iii) preserved OD plasticity after a stroke in the primary somatosensory cortex. Using patch-clamp electrophysiology in vitro, we also show that (iv) local inhibition was significantly reduced in V1 slices of adult EE mice and (v) the GABA/AMPA ratio was like that in 4-wk-old SC-raised animals. These observations were corroborated by in vivo analyses showing that diazepam treatment significantly reduced the OD shift of EE mice after monocular deprivation. Taken together, EE extended the sensitive phase for OD plasticity into late adulthood, rejuvenated V1 after 4 mo of SC-rearing, and protected adult mice from stroke-induced impairments of cortical plasticity. The EE effect was mediated most likely by preserving low juvenile levels of inhibition into adulthood, which potentially promoted adaptive changes in cortical circuits.
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