ArticlePharmaceutical research2014
Comparison of in vitro deposition of pharmaceutical aerosols in an idealized child throat with in vivo deposition in the upper respiratory tract of children.
Article in Pharmaceutical research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 44 citations in OpenAlex.
- Experimentally Informed Numerical Simulations of Spray Deposition and Runoff Doses in a 10-Day-Old Nose Model.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Characterization of Pediatric Extrathoracic Aerosol Deposition with Air-Jet Dry Powder Inhalers.Journal of aerosol science · 2025Article
- The development of a 3D-printed in vitro integrated oro-pharyngeal air-liquid interface cellular throat model for drug transport.Drug delivery and translational research · 2023Article
- Near Elimination of In Vitro Predicted Extrathoracic Aerosol Deposition in Children Using a Spray-Dried Antibiotic Formulation and Pediatric Air-Jet DPI.Pharmaceutical research · 2023Article
- Flow Patterns and Particle Residence Times in the Oral Cavity during Inhaled Drug Delivery.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Targeting of Inhaled Therapeutics to the Small Airways: Nanoleucine Carrier Formulations.Pharmaceutics · 2021Article
- A whole lung in silico model to estimate age dependent particle dosimetry.Scientific reports · 2021Article
- High-Efficiency Dry Powder Aerosol Delivery to Children: Review and Application of New Technologies.Journal of aerosol science · 2021Article
- Exhaled aerosol increases with COVID-19 infection, age, and obesity.Proceedings of the National Academy of Sciences of the United States of America · 2021Observational
- Comparative in-vitro Study of the Trachospray, a New Device for Topical Anaesthesia of the Upper Airway.Medical devices (Auckland, N.Z.) · 2021Article
- Advancement of a Positive-Pressure Dry Powder Inhaler for Children: Use of a Vertical Aerosolization Chamber and Three-Dimensional Rod Array Interface.Pharmaceutical research · 2020Article
- Development of an Inline Dry Powder Inhaler for Oral or Trans-Nasal Aerosol Administration to Children.Journal of aerosol medicine and pulmonary drug delivery · 2020Article
- Factors Determining In Vitro Lung Deposition of Albuterol Aerosol Delivered by Ventolin Metered-Dose Inhaler.Journal of aerosol medicine and pulmonary drug delivery · 2017Article
- The Impact of Inspiratory Flow Rate on Drug Delivery to the Lungs with Dry Powder Inhalers.Pharmaceutical research · 2017Review
- Bridging the Gap Between Science and Clinical Efficacy: Physiology, Imaging, and Modeling of Aerosols in the Lung.Journal of aerosol medicine and pulmonary drug delivery · 2016Review
- Multivariate Analysis of Effects of Asthmatic Patient Respiratory Profiles on the In Vitro Performance of a Reservoir Multidose and a Capsule-Based Dry Powder Inhaler.Pharmaceutical research · 2016Article
- Investigating the airborne transmission pathway - different approaches with the same objectives.Indoor air · 2015Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeDeposition of drug emitted from two commercially available inhalers was measured in an in vitro child oral airway model and compared to existing in vivo data to examine the ability of the child model to replicate in vivo deposition.
methodsIn vitro deposition of drug from a QVAR® pressurized metered dose inhaler (pMDI) and Pulmicort® Turbuhaler® dry powder inhaler (DPI) in an Idealized Child Throat (1) and downstream filter was measured using UV spectroscopy and simulated realistic breathing profiles. Potential effects of ambient relative humidity ranging from 10% to 90% on deposition were also considered.
resultsIn vitro QVAR pMDI deposition in the idealized mouth-throat at 50% RH (39.2 ± 2.3% of delivered dose) compared well (p>0.05) with in vivo extrathoracic deposition in asthmatic children age 8 to 14 (45.8 ± 12.3%). In vitro Turbuhaler DPI deposition in the idealized mouth-throat at 50% RH (69.0 ± 1.5%) matched in vivo extrathoracic deposition (p>0.05) in 6 to 16 year old children with cystic fibrosis (70.4 ± 21.2%). The effects of ambient humidity were found to be insignificant for Turbuhaler and minor for QVAR.
conclusionsThe Idealized Child Throat successfully mimics in vivo deposition data in school age children for the inhalers tested, and may provide a standard platform for optimizing pediatric treatment with inhaled pharmaceutical aerosols.
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